Kobayashi Hiroshi, Imanaka Shogo
Department of Gynecology Ms.Clinic MayOne Kashihara, Nara Japan.
Department of Obstetrics and Gynecology Nara Medical University Kashihara, Nara Japan.
Reprod Med Biol. 2022 Oct 17;21(1):e12488. doi: 10.1002/rmb2.12488. eCollection 2022 Jan-Dec.
Endometriosis is an estrogen-dependent disease and causes pelvic pain and infertility. The limits of current pharmacotherapy in women who desire to become pregnant prompt the development of various targeted molecules for more effective treatment. A review article focused on the unique aspect of cellular metabolic reprogramming of endometriotic cells has been reported. The cellular metabolic pathways are reprogrammed to adapt to a variety of environmental stresses (e.g., nutrient starvation or glucose deprivation, hypoxic stress, excessive reactive oxygen species generation, and other environmental factors). This review aims to summarize macrophage polarization and metabolic reprogramming in endometriosis.
A literature search was performed between January 2000 and March 2022 in the PubMed and Google Scholar databases using a combination of specific terms.
Macrophage cellular metabolism has a marked influence on its phenotype and function. Preclinical studies showed that metabolic conversion toward glycolysis or oxidative phosphorylation drives macrophage polarization to M1 or M2 phenotype, respectively. Such cellular metabolic rewiring can offer new therapeutic opportunities.
A better understanding of metabolic reprogramming biology in endometriosis-associated macrophages is essential in considering novel therapeutic approach for endometriosis. However, there are currently no detailed studies on therapeutic strategies targeting the cellular metabolic properties of endometriosis-associated macrophages.
子宫内膜异位症是一种雌激素依赖性疾病，可导致盆腔疼痛和不孕。当前药物治疗对于有怀孕意愿女性的局限性促使人们研发各种靶向分子以实现更有效的治疗。已有一篇综述文章聚焦于子宫内膜异位细胞独特的细胞代谢重编程方面。细胞代谢途径会被重新编程以适应各种环境应激（如营养饥饿或葡萄糖剥夺、缺氧应激、活性氧过量生成及其他环境因素）。本综述旨在总结子宫内膜异位症中巨噬细胞极化和代谢重编程情况。
于2000年1月至2022年3月期间，在PubMed和谷歌学术数据库中使用特定术语组合进行文献检索。
巨噬细胞的细胞代谢对其表型和功能有显著影响。临床前研究表明，向糖酵解或氧化磷酸化的代谢转变分别驱动巨噬细胞极化为M1或M2表型。这种细胞代谢重排可提供新的治疗机会。
更好地理解子宫内膜异位症相关巨噬细胞中的代谢重编程生物学对于考虑子宫内膜异位症的新治疗方法至关重要。然而，目前尚无针对子宫内膜异位症相关巨噬细胞细胞代谢特性的治疗策略的详细研究。
