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为什么埃博拉病毒不像严重急性呼吸综合征冠状病毒2（SARS-CoV-2）那样引发全球大流行？

Why doesn't Ebola virus cause pandemics like SARS-CoV-2?

作者信息

Popovic Marko

机构信息

School of Life Sciences, Technical University of Munich, Freising, Germany.

出版信息

Microb Risk Anal. 2022 Dec;22:100236. doi: 10.1016/j.mran.2022.100236. Epub 2022 Oct 25.

DOI:10.1016/j.mran.2022.100236
PMID:36312211
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9597532/
Abstract

Ebola virus is among the most dangerous, contagious and deadly etiological causes of viral diseases. However, Ebola virus has never extensively spread in human population and never have led to a pandemic. Why? The mechanistic biophysical model revealing the biothermodynamic background of virus-host interaction) could help us to understand pathogenesis of Ebola virus disease (earlier known as the Ebola hemorrhagic fever). In this paper for the first time the empirical formula, thermodynamic properties of biosynthesis (including the driving force of virus multiplication in the susceptible host), binding constant and thermodynamic properties of binding are reported. Thermodynamic data for Ebola virus were compared with data for SARS-CoV-2 to explain why SARS-CoV-2 has caused a pandemic, while Ebola remains on local epidemic level. The empirical formula of the Ebola virus was found to be CHONPS. Standard Gibbs energy of biosynthesis of the Ebola virus nucleocapsid is -151.59 kJ/C-mol.

摘要

埃博拉病毒是病毒性疾病中最危险、传染性最强且致命的病原体之一。然而，埃博拉病毒从未在人群中广泛传播，也从未引发大流行。原因何在？揭示病毒与宿主相互作用生物热力学背景的机制性生物物理模型，或许能帮助我们理解埃博拉病毒病（先前称为埃博拉出血热）的发病机制。本文首次报道了经验公式、生物合成的热力学性质（包括病毒在易感宿主中增殖的驱动力）、结合常数以及结合的热力学性质。将埃博拉病毒的热力学数据与严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的数据进行比较，以解释为何SARS-CoV-2引发了大流行，而埃博拉病毒仍处于局部流行水平。发现埃博拉病毒的经验公式为CHONPS。埃博拉病毒核衣壳生物合成的标准吉布斯自由能为-151.59千焦/碳-摩尔。

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