Popovic Marko
Institute of Chemistry, Technology and Metallurgy, University of Belgrade, Njegoševa 12, 11000 Belgrade, Serbia.
Microb Risk Anal. 2023 Aug;24:100260. doi: 10.1016/j.mran.2023.100260. Epub 2023 Mar 22.
SARS-CoV-2 has during the last 3 years mutated several dozen times. Most mutations in the newly formed variants have been chemically and thermodynamically characterized. New variants have been declared as variants under monitoring. The European Centre for Disease Prevention and Control has suggested the hypothesis that the new BN.1, CH.1.1 and XBC variants could have properties similar to those of VOC. Thermodynamic properties of new variants have been reported in this manuscript for the first time. Gibbs energy of biosynthesis, as the driving force for viral multiplication, is less negative for the new variants than for the earlier variants. This indicates that the virus has evolved towards decrease in pathogenicity, which leads to less severe forms of COVID-19.
在过去三年中，严重急性呼吸综合征冠状病毒2（SARS-CoV-2）已经发生了几十次变异。新形成的变体中的大多数突变都已进行了化学和热力学表征。新变体已被宣布为监测中的变体。欧洲疾病预防控制中心提出了一种假说，即新的BN.1、CH.1.1和XBC变体可能具有与变异株（VOC）相似的特性。本文首次报道了新变体的热力学性质。作为病毒繁殖驱动力的生物合成吉布斯自由能，新变体比早期变体的负值更小。这表明该病毒已朝着致病性降低的方向进化，从而导致新冠病毒病（COVID-19）的症状不那么严重。
