School of Life Sciences, Technical University of Munich, 85354, Freising, Germany.
Virology. 2022 Oct;575:36-42. doi: 10.1016/j.virol.2022.08.009. Epub 2022 Aug 27.
All processes in nature are driven by negative Gibbs energy. Gibbs energy is used by various viruses and their strains to hijack host cell metabolic machinery. The analysis was made by using the atom counting method to obtain elemental compositions and Gibbs energy of growth of the BA.2 strain of SARS-CoV-2. Moreover, Gibbs energy of binding was determined for the BA.2 strain. The properties of BA.2 were compared to those of Hu-1, Delta and Omicron strains. It is concluded that SARS-CoV-2 has evolved by making its Gibbs energy of binding more negative. Hence, it seems that the change in Gibbs energy of binding plays the major role in SARS-CoV-2 evolution. Therefore, Gibbs energy difference between various strains represents the possible mechanism of Darwinian evolution of viruses. In particular, a virus evolves through mutations, resulting in change in information content, elemental composition, increase in infectivity and decrease in pathogenicity.
自然界中的所有过程都是由负吉布斯自由能驱动的。吉布斯自由能被各种病毒及其毒株用来劫持宿主细胞的代谢机制。该分析使用原子计数法来获得 SARS-CoV-2 的 BA.2 株的元素组成和生长吉布斯自由能。此外，还确定了 BA.2 株的结合吉布斯自由能。将 BA.2 的特性与 Hu-1、Delta 和 Omicron 株进行了比较。结论是，SARS-CoV-2 通过使其结合吉布斯自由能更负来进化。因此，似乎结合吉布斯自由能的变化在 SARS-CoV-2 的进化中起着主要作用。因此，各菌株之间的吉布斯自由能差异代表了病毒达尔文进化的可能机制。特别是，病毒通过突变进化，导致信息含量、元素组成、感染性增加和致病性降低的变化。
