Marcellino Chris, Ransom Chase C, Wijdicks Eelco F
Department of Neurology, Mayo Clinic, Rochester, USA.
Department of Anesthesia, Mayo Clinic, Rochester, USA.
Cureus. 2022 Sep 25;14(9):e29547. doi: 10.7759/cureus.29547. eCollection 2022 Sep.
We describe a 60-year-old female patient who suffered an apparently intentional overdose of lacosamide and who developed status epilepticus secondary to its toxicity, complicated by refractory ventricular arrhythmia necessitating advanced cardiac life support and percutaneous stellate ganglion blockade. Extracorporeal membrane oxygenation was considered, and arterial and venous small-bore sheaths were placed in order to allow for extracorporeal cardiopulmonary resuscitation if cardiac arrest recurred, but they were not ultimately used. She suffered an embolic left middle cerebral artery stroke but otherwise recovered from the episode. This eventful clinical course highlights the dangers of lacosamide in high doses.
我们描述了一名60岁女性患者，她明显故意过量服用了拉科酰胺，并因药物毒性引发癫痫持续状态，并发难治性室性心律失常，需要进行高级心脏生命支持和经皮星状神经节阻滞。考虑过进行体外膜肺氧合，并放置了动脉和静脉小口径鞘管，以便在心脏骤停复发时进行体外心肺复苏，但最终未使用。她发生了栓塞性左大脑中动脉卒中，但在其他方面从该事件中康复。这一曲折的临床过程凸显了高剂量拉科酰胺的危险性。
