Wang Rui, Fan Xiuqin, Lu Yuanyuan, Chen Dawei, Zhao Yunfeng, Qi Kemin
Laboratory of Nutrition and Development, Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Department of Children's Health Care Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Curr Res Food Sci. 2022 Oct 19;5:1976-1984. doi: 10.1016/j.crfs.2022.10.021. eCollection 2022.
Vinegar is widely used in Chinese diet as a traditional condiment, and its functional component acetic acid has been proposed to prevent obesity, while its mechanism is still unclear. Bile acids (BAs) have been reported to have a protective effect on obesity. This study demonstrated that high-fat diet induced obesity (DIO) seriously disturbed BAs balance by significantly decreasing hepatic BAs synthesis and increasing fecal BAs excretion. However, acetate supplemented in the high-fat diet can restore BAs balance by mainly promoting hepatic taurine conjugated BAs (tauro-BAs) synthesis and decreasing fecal tauro-BAs excretion. The tauro-BAs, as the antagonists, inhibited the intestinal-liver farnesoid X receptor (FXR)-fibroblast growth factor 15 (FGF15)-FGF receptor 4 (FGFR4) signaling pathway, and negatively regulated the production of hepatic BAs. Present study provided important clues for further investigation of the mechanism of acetic acid inhibiting DIO.
醋作为一种传统调味品在中国饮食中广泛使用，其功能成分醋酸已被提出具有预防肥胖的作用，但其机制仍不清楚。据报道，胆汁酸（BAs）对肥胖具有保护作用。本研究表明，高脂饮食诱导的肥胖（DIO）通过显著降低肝脏BAs合成和增加粪便BAs排泄，严重扰乱了BAs平衡。然而，高脂饮食中补充醋酸可主要通过促进肝脏牛磺酸结合型胆汁酸（tauro-BAs）合成和减少粪便tauro-BAs排泄来恢复BAs平衡。tauro-BAs作为拮抗剂，抑制肠-肝法尼醇X受体（FXR）-成纤维细胞生长因子15（FGF15）-FGF受体4（FGFR4）信号通路，并对肝脏BAs的产生起负调节作用。本研究为进一步研究醋酸抑制DIO的机制提供了重要线索。
