Bai Ruixue, Ying Xiuquan, Shen Jieqiang, Wu Tingting, Lai Xingyu, Wang Lingyun, Yu Meng, Qi Xiaoya, Mei Ying
Health Management Center, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Department of Food and Nutrition, College of Medical and Life Sciences, Silla University, Busan, South Korea.
Front Nutr. 2022 Oct 13;9:961792. doi: 10.3389/fnut.2022.961792. eCollection 2022.
The prevalence of hyperuricemia (HUA) has been increasing in recent years. HUA is a crucial risk factor for gout and an independent risk factor for cardiovascular diseases (CVDs). Identifying potentially modifiable factors of HUA is vital for preventing gout and even CVDs. This study aimed to explore the associations of fat distribution with HUA among middle-aged and elderly people in Chongqing, China.
A cross-sectional study was conducted between July 2020 and September 2021. People who underwent quantitative computed tomography (QCT) scans were invited to participate in the study. A total of 3,683 individuals whose clinical characteristics and QCT-based fat distribution measurements included visceral fat area (VFA), subcutaneous fat area (SFA), and liver fat content (LFC) were well-recorded were included. HUA was defined as having a serum uric acid level greater than 420.0 μmol/L. Multivariate logistic regression models were used to evaluate the association between these adipose variables and HUA prevalence.
The HUA prevalence was 25.6% (943/3,683), which was 39.6% (817/2,063) in men and 7.8% (126/1,620) in women. In the fully adjusted model (model 4), the comparison of the highest one with the lowest quartiles of adipose variables showed that the multivariable OR (95% confidence intervals) of HUA were 2.08 (1.36-3.16; for trend = 0.001) for VFA, 0.89 (0.63-1.25; for trend = 0.651) for SFA, and 1.83 (1.42-2.34; for trend < 0.0001) for LFC. For VFA, the association was more evident in men than in women.
Higher VFA and LFC were significantly associated with the increased prevalence of HUA in middle-aged and elderly Chinese individuals. VFA and LFC may have a predictive effect on HUA. Controlling visceral and liver fat accumulation may be beneficial for middle-aged and older people. HUA can be prevented with specific effective healthy physical activity and balanced diet guidelines.
近年来，高尿酸血症（HUA）的患病率一直在上升。HUA是痛风的关键危险因素，也是心血管疾病（CVD）的独立危险因素。识别HUA潜在的可改变因素对于预防痛风甚至CVD至关重要。本研究旨在探讨中国重庆中老年人脂肪分布与HUA之间的关联。
于2020年7月至2021年9月进行了一项横断面研究。邀请接受定量计算机断层扫描（QCT）的人参与研究。共纳入3683例个体，其临床特征和基于QCT的脂肪分布测量值，包括内脏脂肪面积（VFA）、皮下脂肪面积（SFA）和肝脏脂肪含量（LFC）均有详细记录。HUA定义为血清尿酸水平大于420.0μmol/L。采用多因素逻辑回归模型评估这些脂肪变量与HUA患病率之间的关联。
HUA患病率为25.6%（943/3683），男性为39.6%（817/2063），女性为7.8%（126/1620）。在完全调整模型（模型4）中，将脂肪变量最高四分位数与最低四分位数进行比较，结果显示，HUA多变量比值比（95%置信区间），VFA为2.08（1.36 - 3.16；趋势P = 0.001），SFA为0.89（0.63 - 1.25；趋势P = 0.651），LFC为1.83（1.42 - 2.34；趋势P < 0.0001）。对于VFA，男性的关联比女性更明显。
较高的VFA和LFC与中国中老年人HUA患病率增加显著相关。VFA和LFC可能对HUA有预测作用。控制内脏和肝脏脂肪堆积可能对中老年人有益。通过特定有效的健康体育活动和均衡饮食指南可预防HUA。
