Suwanchatchai Chawin, Khuancharee Kitsarawut, Tanunyutthawongse Chantra, Wannaiampikul Sivaporn, Haetanurak Photsathorn
Department of Preventive and Community Medicine, Faculty of Medicine, Srinakharinwirot University, Nakhon Nayok 26120, Thailand.
Department of Biochemistry, Faculty of Medicine, Srinakharinwirot University, Bangkok 10110, Thailand.
Iran J Public Health. 2024 Jun;53(6):1361-1371.
Although the prevalence of HUA is increasing, epidemiologic studies on HUA in the middle-aged and elderly population are limited. The present study aimed to calculate the prevalence and evaluate the sex-related associations between metabolic parameters and hyperuricemia (HUA) among middle-aged and elderly adults.
This was a population-based cross-sectional study from 2018 to 2019 in rural areas of Nakhon Nayok Province, Thailand. We enrolled 780 subjects aged 40 yr and over for health check-ups and examination surveys. The age-standardized prevalence of HUA was estimated by the direct method. A multiple logistic regression was performed to identify the potential risk factors associated with HUA.
The prevalence of HUA were 30.9% (42% in males vs. 20% in females). Elderly adults were associated with a 35% increase in the risk of HUA. Obesity was found to be strongly associated with an increased prevalence of HUA in both sexes. Hypertriglyceridemia (51% increase in males vs. 23% increase in females), and high fasting glucose (90% increase in males vs. 49% increase in females) were also associated risk factors for HUA in both sexes. However, low high-density lipoprotein was only associated with a 67% increase in the risk of HUA in females.
The age-standardized prevalence of HUA among females is relatively lower than in males. This study also revealed that obesity is strongly associated with HUA in both sexes.
尽管高尿酸血症（HUA）的患病率在上升，但针对中老年人群高尿酸血症的流行病学研究有限。本研究旨在计算中老年成年人中高尿酸血症的患病率，并评估代谢参数与高尿酸血症（HUA）之间的性别相关关联。
这是一项于2018年至2019年在泰国那空那育府农村地区开展的基于人群的横断面研究。我们纳入了780名年龄在40岁及以上的受试者进行健康检查和调查。采用直接法估计高尿酸血症的年龄标准化患病率。进行多因素逻辑回归分析以确定与高尿酸血症相关的潜在危险因素。
高尿酸血症的患病率为30.9%（男性为42%，女性为20%）。老年人患高尿酸血症的风险增加35%。肥胖被发现与男女两性高尿酸血症患病率的增加密切相关。高甘油三酯血症（男性增加51%，女性增加23%）和空腹血糖升高（男性增加90%，女性增加49%）也是男女两性高尿酸血症的相关危险因素。然而，低高密度脂蛋白仅与女性高尿酸血症风险增加67%相关。
女性高尿酸血症的年龄标准化患病率相对低于男性。本研究还表明，肥胖与男女两性的高尿酸血症密切相关。
