Cotler Joseph, Katz Ben Z, Reurts-Post Corine, Vermeulen Ruud, Jason Leonard A
Department of Psychology, DePaul University, Chicago, IL, USA.
Feinberg School of Medicine, Northwestern University, Evanston, IL, USA.
Fatigue. 2020;8(4):205-213. doi: 10.1080/21641846.2020.1845287. Epub 2020 Nov 16.
Past research has found high rates of hyperventilation in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), but hyperventilation can be influenced by psychological factors. Clinical respiratory rates have been less frequently assessed.
This study aimed to identify the predictors of rapid respiratory rates in patients referred to an outpatient clinic specializing in ME/CFS.
Adults ( = 216) referred to an outpatient clinic specializing in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) participated in a two-day cardiopulmonary exercise test. As part of that evaluation, subjects had resting respiratory rates measured on two consecutive days. The current study used questionnaires to assess the relationship between tachypnea (rapid respiratory rates) and a variety of domains including post-exertional malaise (PEM), a common complaint in patients with ME/CFS, and psychiatric/somatic symptoms, using hierarchical logistic regression analysis.
PEM was a significant predictor of tachypnea, while psychological/somatic assessments and sedentary behaviors were not significantly predictive of tachypnea.
These findings suggest that respiratory rate may be useful as an objective clinical metric of PEM, and potentially ME/CFS.
过去的研究发现，肌痛性脑脊髓炎/慢性疲劳综合征（ME/CFS）患者的过度换气发生率很高，但过度换气可能会受到心理因素的影响。临床呼吸频率的评估则较少。
本研究旨在确定转诊至一家专门治疗ME/CFS的门诊诊所的患者呼吸急促的预测因素。
216名转诊至一家专门治疗肌痛性脑脊髓炎/慢性疲劳综合征（ME/CFS）的门诊诊所的成年人参加了为期两天的心肺运动测试。作为该评估的一部分，受试者连续两天测量静息呼吸频率。本研究使用问卷调查，采用分层逻辑回归分析，评估呼吸急促（快速呼吸频率）与包括运动后不适（PEM，ME/CFS患者的常见症状）以及精神/躯体症状在内的各种领域之间的关系。
运动后不适是呼吸急促的一个重要预测因素，而心理/躯体评估和久坐行为对呼吸急促没有显著预测作用。
这些发现表明，呼吸频率可能作为运动后不适以及潜在的ME/CFS的一种客观临床指标。
