Yang Jiali, Fu Qiqi, Jiang Hui, Li Yinghua, Liu Muqing
School of Information Science and Technology, Fudan University, Shanghai, China.
Academy for Engineering and Technology, Fudan University, Shanghai, China.
Front Oncol. 2022 Oct 13;12:1022973. doi: 10.3389/fonc.2022.1022973. eCollection 2022.
Osteosarcoma (OS) is the most common primary malignant bone tumor that mainly affects the pediatric and adolescent population; limb salvage treatment has become one of the most concerned and expected outcomes of OS patients recently. Phototherapy (PT), as a novel, non-invasive, and efficient antitumor therapeutic approach including photodynamic therapy (PDT), photothermal therapy (PTT), and photobiomodulation therapy (PBMT), has been widely applied in superficial skin tumor research and clinical treatment. OS is the typical deep tumor, and its phototherapy research faces great limitations and challenges. Surprisingly, pulse mode LED light can effectively improve tissue penetration and reduce skin damage caused by high light intensity and has great application potential in deep tumor research. In this review, we discussed the research progress and related molecular mechanisms of phototherapy in the treatment of OS, mainly summarized the status quo of blue light PBMT in the scientific research and clinical applications of tumor treatment, and outlooked the application prospect of pulsed blue LED light in the treatment of OS, so as to further improve clinical survival rate and prognosis of OS treatment and explore corresponding cellular mechanisms.
骨肉瘤（OS）是最常见的原发性恶性骨肿瘤，主要影响儿童和青少年人群；保肢治疗已成为近年来骨肉瘤患者最受关注和期待的治疗结果之一。光疗（PT）作为一种新型、非侵入性且高效的抗肿瘤治疗方法，包括光动力疗法（PDT）、光热疗法（PTT）和光生物调节疗法（PBMT），已广泛应用于浅表皮肤肿瘤的研究和临床治疗。骨肉瘤是典型的深部肿瘤，其光疗研究面临巨大的局限性和挑战。令人惊讶的是，脉冲模式LED光可以有效提高组织穿透率，并减少高光强度引起的皮肤损伤，在深部肿瘤研究中具有巨大的应用潜力。在这篇综述中，我们讨论了光疗在骨肉瘤治疗中的研究进展及相关分子机制，主要总结了蓝光PBMT在肿瘤治疗科研和临床应用中的现状，并展望了脉冲蓝光LED光在骨肉瘤治疗中的应用前景，以期进一步提高骨肉瘤治疗的临床生存率和预后，并探索相应的细胞机制。
