Elbehiry Ayman, Marzouk Eman, Abalkhail Adil
Department of Public Health, College of Applied Medical Sciences, Qassim University, P.O. Box 6666, Buraydah 51452, Saudi Arabia.
Vaccines (Basel). 2025 Jul 3;13(7):725. doi: 10.3390/vaccines13070725.
() is one of the most prevalent chronic bacterial infections globally, significantly contributing to gastritis, peptic ulcers, and gastric malignancies. Its pathogenesis involves a complex array of virulence factors-including , , and urease-which facilitate mucosal colonization, immune evasion, and persistent inflammation. A major challenge in vaccine development is the bacterium's ability to manipulate both innate and adaptive immune responses, resulting in limited natural clearance and long-term persistence. This review synthesizes pathogenesis and host immune dynamics, highlighting their implications for vaccine design. By elucidating the molecular and cellular mechanisms underlying host-pathogen interactions, we explore how these insights inform antigen selection, adjuvant optimization, and delivery strategies. By integrating basic science with translational objectives, this review aims to support the development of an effective vaccine, addressing global health needs, particularly in regions with a high infection burden and limited access to treatment.
（某细菌）是全球最普遍的慢性细菌感染之一，对胃炎、消化性溃疡和胃癌有显著影响。其发病机制涉及一系列复杂的毒力因子，包括（列举的毒力因子）和尿素酶，这些因子有助于黏膜定植、免疫逃逸和持续炎症。疫苗开发中的一个主要挑战是该细菌操纵先天免疫和适应性免疫反应的能力，导致自然清除有限和长期持续存在。本综述综合了（某细菌）的发病机制和宿主免疫动态，强调了它们对疫苗设计的影响。通过阐明宿主 - 病原体相互作用的分子和细胞机制，我们探讨了这些见解如何为抗原选择、佐剂优化和递送策略提供信息。通过将基础科学与转化目标相结合，本综述旨在支持开发一种有效的（某细菌）疫苗，以满足全球健康需求，特别是在感染负担高且治疗机会有限的地区。
