一种用于生物相关阳离子的水溶性膜转运蛋白。

Yang Kylie, Boles Jessica E, White Lisa J, Hilton Kira L F, Lai Hin Yuk, Long Yifan, Hiscock Jennifer R, Haynes Cally J E

Chemistry Department, UCL 20 Gordon Street London WC1H 0AJ UK

School of Chemistry and Forensic Science, University of Kent Canterbury Kent CT2 7NH UK

RSC Adv. 2022 Sep 29;12(43):27877-27880. doi: 10.1039/d2ra05314d. eCollection 2022 Sep 28.

Synthetic ionophores are promising therapeutic targets, yet poor water solubility limits their potential for translation into the clinic. Here we report a water-soluble, supramolecular self-associating amphiphile that functions as a cation uniporter in synthetic vesicle systems, deriving mechanistic insight through planar bilayer patch clamp experiments.

合成离子载体是很有前景的治疗靶点，但水溶性差限制了它们转化为临床应用的潜力。在此，我们报告了一种水溶性超分子自缔合两亲物，它在合成囊泡系统中作为阳离子单向转运体发挥作用，并通过平面双层膜片钳实验获得了机制上的见解。