Nozohour Yaser, Maham Masoud, Dalir-Naghadeh Bahram
Department of Internal Medicine and Clinical Pathology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
Vet Res Forum. 2022 Sep;13(3):357-362. doi: 10.30466/vrf.2021.528973.3171. Epub 2022 Sep 15.
Gastrointestinal motility disorders include increased or decreased movements. Other studies have shown that herbal components, for example, essential oils can modify the increase and decrease of gastrointestinal movements of ruminants. The 1,8-cineole being obtained from the essential oil of many plants has several effects. The present study has investigated the effect of 1,8-cineole on the contractility of bovine ileum smooth muscle. The experiment was performed on the circular smooth muscle of ileum samples taken from slaughtered cows in the organ bath. Seven cumulative concentrations of 1,8-cineole from 1.00 to 1,000 µg mL were added to tissue samples. The used solution was Tyrode's solution aerated with a mixture of 95.00% oxygen and 5.00% carbon dioxide, and the temperature was set at 37.00 ˚C. The effects of 1,8-cineole on baseline contractions and three induced contractions with barium chloride, potassium chloride, and carbachol were investigated. The effects of 1,8-cineole, and verapamil (standard calcium channel blocker) on calcium channels were assessed. The results revealed that 1,8-cineole significantly inhibited spontaneous contractions as well as all spasmogen-induced contractions. The 1,8-cineole exerts its myorelaxant properties by inhibiting calcium channels in smooth muscle. It seems that 1,8-cineole has a good potential for producing antispasmodics or gastrointestinal motility modulators in veterinary medicine.
胃肠动力障碍包括运动增加或减少。其他研究表明，草药成分，例如精油，可以改变反刍动物胃肠运动的增加和减少。从许多植物的精油中提取的1,8-桉叶素具有多种作用。本研究调查了1,8-桉叶素对牛回肠平滑肌收缩性的影响。实验在器官浴中取自屠宰奶牛的回肠环形平滑肌上进行。将1.00至1000μg/mL的七种累积浓度的1,8-桉叶素添加到组织样本中。所用溶液是用95.00%氧气和5.00%二氧化碳的混合物曝气的台氏液，温度设定为37.00˚C。研究了1,8-桉叶素对基线收缩以及用氯化钡、氯化钾和卡巴胆碱诱导的三种收缩的影响。评估了1,8-桉叶素和维拉帕米（标准钙通道阻滞剂）对钙通道的影响。结果显示，1,8-桉叶素显著抑制自发收缩以及所有致痉剂诱导的收缩。1,8-桉叶素通过抑制平滑肌中的钙通道发挥其肌松特性。看来1,8-桉叶素在兽医学中具有生产抗痉挛药或胃肠动力调节剂的良好潜力。
