子宫内暴露于己烯雌酚后抗体反应的改变。
Alterations of the antibody response following in utero exposure to diethylstilbestrol.
作者信息
Luster M I, Faith R E, McLachlan J A
出版信息
Bull Environ Contam Toxicol. 1978 Oct;20(4):433-7. doi: 10.1007/BF01683543.
PMID:363205
Abstract
The antibody response to SRBC and E. coli 0127 lipopolysaccharide were determined in offspring from mice exposed in utero to diethylstilbestrol. The antibody response to SRBC, a T-cell dependent antigen, was similar in control and exposed animals. In contrast, the LPS antibody response was suppressed in treated females and enhanced in treated males. These studies indicated that in utero exposure to DES alters the humoral immune system to T-independent antigens.
摘要
测定了子宫内暴露于己烯雌酚的小鼠后代对绵羊红细胞（SRBC）和大肠杆菌0127脂多糖的抗体反应。对T细胞依赖性抗原SRBC的抗体反应在对照动物和暴露动物中相似。相比之下，经处理的雌性小鼠的脂多糖抗体反应受到抑制，而经处理的雄性小鼠的该反应增强。这些研究表明，子宫内暴露于己烯雌酚会改变对T细胞非依赖性抗原的体液免疫系统。
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