Sesquiterpenes and Steroids from an Endophytic .

A chemical investigation on the EtOAc extract of the endophytic fungus SCBG-8 led to the isolation of eight new sesquiterpenes eutyscoparins A-H (), one C-28 steroid eutyscoparene A (), one triterpenoid eutyscoparene B (), six known terpenoids, and two known steroids. Their structures including absolute configurations were established on the basis of spectroscopic data analysis, single-crystal X-ray diffraction experiments, and electronic circular dichroism (ECD) calculations. Compound displayed antibacterial activity against and MRSA (methicillin-resistant ) with MIC values of 6.3 μg/mL.