Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, People's Republic of China.
University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China.
J Nat Prod. 2021 Jun 25;84(6):1715-1724. doi: 10.1021/acs.jnatprod.0c01167. Epub 2021 May 25.
A chemical investigation on the EtOAc extract of the endophytic fungus SCBG-8 led to the isolation of eight new sesquiterpenes eutyscoparins A-H (), one C-28 steroid eutyscoparene A (), one triterpenoid eutyscoparene B (), six known terpenoids, and two known steroids. Their structures including absolute configurations were established on the basis of spectroscopic data analysis, single-crystal X-ray diffraction experiments, and electronic circular dichroism (ECD) calculations. Compound displayed antibacterial activity against and MRSA (methicillin-resistant ) with MIC values of 6.3 μg/mL.
从内生真菌 SCBG-8 的 EtOAc 提取物中进行的化学研究导致分离出了八种新的倍半萜 eutyscoparins A-H (), 一种 C-28 甾体 eutyscoparene A (), 一种三萜 eutyscoparene B (), 六种已知萜类化合物和两种已知甾体化合物。基于光谱数据分析、单晶 X 射线衍射实验和电子圆二色性 (ECD) 计算，确定了它们的结构包括绝对构型。化合物 对 和 MRSA（耐甲氧西林金黄色葡萄球菌）显示出抗菌活性，MIC 值分别为 6.3 μg/mL。
