El-Hawary Seham S, Moawad Abeer S, Bahr Hebatallah S, Abdelmohsen Usama Ramadan, Mohammed Rabab
Department of Pharmacognosy, Faculty of Pharmacy, Cairo University 11936 Cairo Egypt.
Department of Pharmacognosy, Faculty of Pharmacy, Beni-Suef University 62514 Beni-Suef Egypt
RSC Adv. 2020 Jun 9;10(37):22058-22079. doi: 10.1039/d0ra04290k. eCollection 2020 Jun 8.
The endophytic fungus is considered as an enormous source of chemical leads with promising biological activities. Different species have proved their ability to produce plenty of secondary metabolites including butenolides, alkaloids, terpenoids, cytochalasins, phenalenones, ρ-terphenyls, xanthones, sterols, diphenyl ether and anthraquinone derivatives with diverse biological activities, such as anti-cancer, antifungal, anti-bacterial, anti-viral, anti-inflammatory, antitrypanosomal and antileishmanial activities. From January 2015 until December 2019, three hundred and sixty-one secondary metabolites were reported from different endophytic species. This review discusses the isolated secondary metabolites from different endophytic species reported from January 2015 to December 2019 along with their reported biological activities and structural aspects whenever applicable.
内生真菌被认为是具有潜在生物活性的化学先导物的巨大来源。不同的物种已证明它们能够产生大量次生代谢产物,包括丁烯内酯、生物碱、萜类化合物、细胞松弛素、菲醌、ρ-三联苯、呫吨酮、甾醇、二苯醚和蒽醌衍生物,这些次生代谢产物具有多种生物活性,如抗癌、抗真菌、抗菌、抗病毒、抗炎、抗锥虫和抗利什曼原虫活性。从2015年1月到2019年12月,不同内生真菌物种共报道了361种次生代谢产物。本综述讨论了2015年1月至2019年12月报道的不同内生真菌物种中分离出的次生代谢产物,以及它们已报道的生物活性和适用时的结构方面。