Felson D T, Naimark A, Anderson J, Kazis L, Castelli W, Meenan R F
Arthritis Rheum. 1987 Aug;30(8):914-8. doi: 10.1002/art.1780300811.
To investigate the prevalence of osteoarthritis (OA) of the knee in elderly subjects, we studied the Framingham Heart Study cohort, a population-based group. During the eighteenth biennial examination, we evaluated the cohort members for OA of the knee by use of medical history, physical examination, and anteroposterior (standing) radiograph of the knees. Radiographs were obtained on 1,424 of the 1,805 subjects (79%). Their ages ranged from 63-94 years (mean 73). Radiographs were read by a radiologist who specializes in bone and joint radiology, and were graded 0-4 according to the scale described by Kellgren and Lawrence. OA was defined as grade 2 changes (definite osteophytes), or higher, in either knee. Radiographic evidence of OA increased with age, from 27% in subjects younger than age 70, to 44% in subjects age 80 or older. There was a slightly higher prevalence of radiographic changes of OA in women than in men (34% versus 31%); however, there was a significantly higher proportion of women with symptomatic disease (11% of all women versus 7% of all men; P = 0.003). The age-associated increase in OA was almost entirely the result of the marked age-associated increase in the incidence of OA in the women studied. This study extends current knowledge about OA of the knee to include elderly subjects, and shows that the prevalence of knee OA increases with age throughout the elderly years.
为了调查老年人群中膝关节骨关节炎（OA）的患病率，我们研究了弗明汉心脏研究队列，这是一个基于人群的群组。在第18次两年一次的检查中，我们通过病史、体格检查以及膝关节前后位（站立位）X线片对队列成员的膝关节OA进行评估。在1805名受试者中的1424名（79%）获得了X线片。他们的年龄在63 - 94岁之间（平均73岁）。X线片由一位专门从事骨与关节放射学的放射科医生阅片，并根据Kellgren和Lawrence描述的量表分为0 - 4级。OA被定义为任一膝关节出现2级改变（明确的骨赘）或更高等级。OA的X线证据随年龄增加，在70岁以下的受试者中为27%，在80岁及以上的受试者中为44%。女性OA的X线改变患病率略高于男性（34%对31%）；然而，有症状疾病的女性比例显著高于男性（所有女性中的11%对所有男性中的7%；P = 0.003）。与年龄相关的OA增加几乎完全是所研究女性中OA发病率显著的年龄相关增加的结果。这项研究将关于膝关节OA的现有知识扩展到了老年人群，并表明在整个老年阶段膝关节OA的患病率随年龄增加。
