护理干预对乳腺癌患者性生活质量的影响：系统评价和荟萃分析。
Effectiveness of nursing interventions on the sexual quality of life of patients with breast cancer: A systematic review and meta-analysis.
机构信息
School of Nursing, Zhejiang Chinese Medical University, Hangzhou, China.
Nursing Department, Zhejiang Provincial People's Hospital, Hangzhou, China.
出版信息
PLoS One. 2022 Nov 3;17(11):e0277221. doi: 10.1371/journal.pone.0277221. eCollection 2022.
BACKGROUND
Although many studies have reported the effectiveness of nursing interventions on the sexual quality of life of patients with breast cancer, the results have not been synthesized. This study aims to assess the effectiveness of nursing interventions on the sexual quality of life of patients with breast cancer.
REVIEW METHODS
A comprehensive search was conducted in 11 databases from inception to October 7, 2021. Studies evaluating the effects of nursing interventions on sexual quality of life were included. Study selection, data extraction, and risk of bias assessment were performed by two independent reviewers.
RESULTS
This review pooled 38 studies with 3,664 participants. Meta-analysis results showed that nursing interventions significantly improved sexual quality of life, including sexual function (standardized mean difference [SMD] = 0.98, 95% confidence interval [CI] = [0.60-1.37], P < 0.001) and sexual satisfaction (SMD = 0.99, 95% CI = [0.41-1.57], P < 0.001). In addition, depression (SMD = -1.16, 95% CI = [-2.08--0.24], P = 0.01) and general quality of life (SMD = 0.20, 95% CI = [0.08-0.33], P = 0.002) were significantly improved, but body image (SMD = 0.17, 95% CI = [-0.08-0.41], P = 0.19) and anxiety (SMD = -0.45, 95% CI = [-0.93-0.02], P = 0.06) did not significantly improve. Subgroup analysis showed that nursing interventions had a stronger long-term effect on sexual function (SMD = 1.15, 95% CI = [0.51-1.80], P = P < 0.001) and was more effective in younger patients (SMD = 1.43, 95% CI = [0.63-2.23], P = P < 0.001). Nursing interventions showed a statistically significant short-term effect on sexual satisfaction (SMD = 1.32, 95% CI = [0.44-2.20], P = 0.003) and a significant effect in older patients (SMD = 1.27, 95% CI = [0.46-2.08], P = 0.002).
CONCLUSIONS
Nursing intervention may be an effective way to improve the sexual quality of life of patients with breast cancer. Nursing interventions had a stronger long-term effect on sexual function, and the group with the strongest effect is the younger patients. Nursing interventions showed a significant short-term effect on sexual satisfaction, and older patients had significant improvement in sexual satisfaction.
背景
尽管许多研究报告了护理干预对乳腺癌患者性生活质量的有效性，但结果尚未综合。本研究旨在评估护理干预对乳腺癌患者性生活质量的影响。
方法
从建库到 2021 年 10 月 7 日，全面检索 11 个数据库。纳入评估护理干预对乳腺癌患者性生活质量影响的研究。由两名独立评审员进行研究选择、数据提取和偏倚风险评估。
结果
本综述共纳入 38 项研究，共计 3664 名参与者。荟萃分析结果表明，护理干预可显著改善性生活质量，包括性功能（标准化均数差[SMD] = 0.98，95%置信区间[CI] = [0.60-1.37]，P < 0.001）和性满意度（SMD = 0.99，95% CI = [0.41-1.57]，P < 0.001）。此外，抑郁（SMD = -1.16，95% CI = [-2.08--0.24]，P = 0.01）和一般生活质量（SMD = 0.20，95% CI = [0.08-0.33]，P = 0.002）也显著改善，但身体形象（SMD = 0.17，95% CI = [-0.08-0.41]，P = 0.19）和焦虑（SMD = -0.45，95% CI = [-0.93-0.02]，P = 0.06）则没有显著改善。亚组分析显示，护理干预对性功能的长期影响更强（SMD = 1.15，95% CI = [0.51-1.80]，P < 0.001），对年轻患者更有效（SMD = 1.43，95% CI = [0.63-2.23]，P < 0.001）。护理干预对性满意度有短期的统计学显著影响（SMD = 1.32，95% CI = [0.44-2.20]，P = 0.003），对老年患者的影响更为显著（SMD = 1.27，95% CI = [0.46-2.08]，P = 0.002）。
结论
护理干预可能是改善乳腺癌患者性生活质量的有效方法。护理干预对性功能的长期影响更强，作用最强的人群是年轻患者。护理干预对性满意度有明显的短期影响，老年患者的性满意度也有显著改善。
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