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丹参酮 IIA 通过调控 NLRP3 炎性小体激活和 Th17 细胞分化改善大鼠心肌缺血/再灌注损伤。

Tanshinone IIA ameliorates myocardial ischemia/reperfusion injury in rats by regulation of NLRP3 inflammasome activation and Th17 cells differentiation.

机构信息

Master. First Teaching Hospital of Tianjin University of Traditional Chinese Medicine - National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion - Tianjin, China.

Bachelor. First Teaching Hospital of Tianjin University of Traditional Chinese Medicine - National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion - Tianjin, China.

出版信息

Acta Cir Bras. 2022 Oct 28;37(7):e370701. doi: 10.1590/acb370701. eCollection 2022.

DOI:10.1590/acb370701
PMID:36327403
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9633015/
Abstract

PURPOSE

Tanshinone IIA is a well-known lipophilic active constituent refined from traditional Chinese medicines, danshen. It has been previously demonstrated to possess various biological properties, including anti-inflammatory, antioxidant, promoting angiogenesis effect and so on. However, the mechanism of tanshinone IIA on myocardial ischemia-reperfusion injury (MI/RI) remains unclear. In this study, we investigated the effect of tanshinone IIA on MI/RI.

METHODS

MI/RI rat models were set up. Echocardiographic evaluation and hematoxylin and eosin staining were performed to analyze the cardiac function and morphology of MI/RI. Western blot was conducted for the detection of protein expression of pyrin domain containing 3 (NLRP3) and caspase-1 in heart tissues. Flow cytometry and real-time polymerase chain reaction were used for the detection of proinflammatory cytokines and Th17 cells differentiation.

RESULTS

We found that tanshinone IIA alleviated the myocardial damage of MI/RI, ameliorated the overall and local inflammatory reaction, and produced a cardioprotective effect by inhibiting of NLRP3 inflammasome activation and Th17/Treg cells differentiation.

CONCLUSIONS

Our results highlighted the cardio-protective effect of tanshinone IIA on MI/RI and uncovered its underlying mechanism related to the NLRP3 inflammasome inhibition and the modulation of Th17/Treg cells differentiation.

摘要

目的

丹参酮 IIA 是一种从传统中药丹参中提取的亲脂性活性成分，具有多种生物学特性，包括抗炎、抗氧化、促进血管生成等。然而，丹参酮 IIA 对心肌缺血再灌注损伤（MI/RI）的作用机制尚不清楚。在本研究中，我们研究了丹参酮 IIA 对 MI/RI 的作用。

方法

建立 MI/RI 大鼠模型。进行超声心动图评估和苏木精-伊红染色，以分析 MI/RI 大鼠的心脏功能和形态。通过 Western blot 检测心脏组织中吡喃结构域包含蛋白 3（NLRP3）和半胱氨酸天冬氨酸蛋白酶-1（caspase-1）的蛋白表达。通过流式细胞术和实时聚合酶链反应检测促炎细胞因子和 Th17 细胞分化。

结果

我们发现丹参酮 IIA 减轻了 MI/RI 引起的心肌损伤，改善了整体和局部炎症反应，并通过抑制 NLRP3 炎性小体激活和 Th17/Treg 细胞分化产生了心脏保护作用。

结论

我们的结果强调了丹参酮 IIA 对 MI/RI 的心脏保护作用，并揭示了其抑制 NLRP3 炎性小体和调节 Th17/Treg 细胞分化的潜在机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccb6/9633015/bdf85ae44349/1678-2674-acb-37-7-e370701-gf05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccb6/9633015/eb34207dc7bb/1678-2674-acb-37-7-e370701-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccb6/9633015/1427b4c3fd54/1678-2674-acb-37-7-e370701-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccb6/9633015/9cbac5a57cb8/1678-2674-acb-37-7-e370701-gf03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccb6/9633015/5fde5b848e9a/1678-2674-acb-37-7-e370701-gf04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccb6/9633015/bdf85ae44349/1678-2674-acb-37-7-e370701-gf05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccb6/9633015/eb34207dc7bb/1678-2674-acb-37-7-e370701-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccb6/9633015/1427b4c3fd54/1678-2674-acb-37-7-e370701-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccb6/9633015/9cbac5a57cb8/1678-2674-acb-37-7-e370701-gf03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccb6/9633015/5fde5b848e9a/1678-2674-acb-37-7-e370701-gf04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccb6/9633015/bdf85ae44349/1678-2674-acb-37-7-e370701-gf05.jpg

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