Department of Biomedical Engineering, Ulsan National Institute of Science and Technology (UNIST), 50, UNIST-gil, Eonyang-eup, Ulju-gun, 44919 Ulsan, Republic of Korea.
Department of Biomedical Engineering, Ulsan National Institute of Science and Technology (UNIST), 50, UNIST-gil, Eonyang-eup, Ulju-gun, 44919 Ulsan, Republic of Korea.
J Control Release. 2022 Dec;352:685-699. doi: 10.1016/j.jconrel.2022.10.054. Epub 2022 Nov 9.
Three-dimensional printing enables precise and on-demand manufacture of customizable drug delivery systems to advance healthcare toward the goal of personalized medicine. However, major challenges remain in realizing personalized drug delivery that fits a patient-specific drug dosing schedule using local drug delivery systems. In this study, a user-designed device is developed as implantable therapeutics that can realize personalized drug release kinetics by programming the inner structural design on the microscale. The drug release kinetics required for various treatments, including dose-dense therapy and combination therapy, can be implemented by controlling the dosage and combination of drugs along with the rate, duration, initiation time, and time interval of drug release according to the device layer design. After implantation of the capsular device in mice, the in vitro-in vivo and pharmacokinetic evaluation of the device is performed, and the therapeutic effect of the developed device is achieved through the local release of doxorubicin. The developed user-designed device provides a novel platform for developing next-generation drug delivery systems for personalized and localized therapy.
三维打印技术能够精确、按需制造定制药物输送系统，推动医疗保健向个性化医学的目标发展。然而，在使用局部药物输送系统实现符合患者特定药物剂量方案的个性化药物输送方面，仍然存在重大挑战。在这项研究中，开发了一种用户设计的设备作为可植入疗法，通过在微观尺度上编程内部结构设计，可以实现个性化的药物释放动力学。通过控制药物的剂量和组合，以及根据设备层设计控制药物释放的速度、持续时间、起始时间和时间间隔，可以实现各种治疗方法所需的药物释放动力学，包括剂量密集型治疗和联合治疗。在将胶囊设备植入小鼠体内后，对设备进行体外-体内和药代动力学评估，并通过局部释放阿霉素来实现开发设备的治疗效果。所开发的用户设计设备为开发下一代用于个性化和局部治疗的药物输送系统提供了一个新的平台。
