Department of Critical Care Medicine, Division of Hematology and Oncology, Mayo Clinic Arizona, 5777 East Mayo Boulevard, Phoenix, AZ 85054, USA.
Department of Medicine, Emory University Hospital, 550 Peachtree Street Northeast, Atlanta, GA 30308, USA.
Infect Dis Clin North Am. 2022 Dec;36(4):735-748. doi: 10.1016/j.idc.2022.07.001.
Both cytokine release syndrome (CRS) and sepsis are clinical syndromes rather than distinct diseases and share considerable overlap. It can often be challenging to distinguish between the two, but it is important given the availability of targeted treatment options. In addition, several other clinical syndromes overlap with CRS and sepsis, further making it difficult to differentiate them. This has particularly been highlighted in the recent coronavirus disease-2019 pandemic. As we start to understand the differences in the inflammatory markers and presentations in these syndromes, hopefully we will be able to enhance treatment and improve outcomes.
细胞因子释放综合征 (CRS) 和脓毒症均为临床综合征而非独立疾病，且具有显著的重叠性。两者之间的区分往往具有挑战性，但鉴于目前已有针对这些疾病的治疗选择，明确区分两者非常重要。此外，还有其他几种临床综合征与 CRS 和脓毒症重叠，进一步增加了区分难度。这在最近的 2019 冠状病毒病大流行中尤为突出。随着我们开始了解这些综合征中炎症标志物和临床表现的差异，我们有望能够改进治疗方法并改善预后。
