Department of Biochemistry, Kangwon National University, Chuncheon 24341, Korea.
BMB Rep. 2022 Dec;55(12):577-586. doi: 10.5483/BMBRep.2022.55.12.141.
Stress granules (SGs) are stress-induced subcellular compartments, which carry out a particular function to cope with stress. These granules protect cells from stress-related damage and cell death through dynamic sequestration of numerous ribonucleoproteins (RNPs) and signaling proteins, thereby promoting cell survival under both physiological and pathological condition. During tumorigenesis, cancer cells are repeatedly exposed to diverse stress stimuli from the tumor microenvironment, and the dynamics of SGs is often modulated due to the alteration of gene expression patterns in cancer cells, leading to tumor progression as well as resistance to anticancer treatment. In this mini review, we provide a brief discussion about our current understanding of the fundamental roles of SGs during physiological stress and the effect of dysregulated SGs on cancer cell fitness and cancer therapy. [BMB Reports 2022; 55(12): 577-586].
应激颗粒（SGs）是应激诱导的细胞内区室，具有应对应激的特定功能。这些颗粒通过动态隔离大量核糖核蛋白（RNPs）和信号蛋白来保护细胞免受应激相关损伤和细胞死亡，从而促进生理和病理条件下的细胞存活。在肿瘤发生过程中，癌细胞反复受到肿瘤微环境中各种应激刺激的影响，由于癌细胞中基因表达模式的改变，SGs 的动态常常受到调节，导致肿瘤进展以及对癌症治疗的耐药性。在这篇综述中，我们简要讨论了我们目前对 SGs 在生理应激过程中的基本作用的理解，以及失调的 SGs 对癌细胞适应性和癌症治疗的影响。[BMB 报告 2022;55(12):577-586]。
