Departamento de Química Orgánica e Inorgánica, Facultad de Química, Universidad de Oviedo, Julián Claveria 8, 33006 Asturias, Oviedo, Spain.
Angew Chem Int Ed Engl. 2023 Jan 9;62(2):e202215094. doi: 10.1002/anie.202215094. Epub 2022 Dec 2.
Several mechanochemically heated processes have been published in recent years. However, precise control over the mechanochemical catalysed coupling reactions remained elusive. A recent report from Leitch, Browne and co-workers demonstrated how a programmable jar heater manifold delivers an efficient methodology for the Suzuki-Miyaura-type cross coupling reaction of aryl sulfamates and aryl boronic acid species. This methodology can be readily upscaled 200-fold using twin-screw extrusion methodologies.
近年来已经有几个机械化学加热过程被公布。然而，对于机械化学催化偶联反应的精确控制仍然难以捉摸。最近，Leitch、Browne 和同事的一篇报道展示了可编程罐式加热器歧管如何为芳基磺酸盐和芳基硼酸物种的 Suzuki-Miyaura 型交叉偶联反应提供一种有效的方法。这种方法可以很容易地通过双螺杆挤出方法放大 200 倍。
