Department of Medicine (retired), Hadassah University Hospital Jerusalem, Israel.
Clinical Utility Department, Sanz Medical Center, Laniado Hospital, Netanya and School of Public Health, University of Tel Aviv, Israel.
Prev Med. 2022 Nov;164:107326. doi: 10.1016/j.ypmed.2022.107326. Epub 2022 Nov 2.
We retrieved data on a cohort of medical patients at a regional Israeli hospital. The dependent variable was non-COVID-19 hospital mortality; the independent variables were vaccination status, age, and laboratory data. Serum sodium, age, serum creatinine, and COVID-19 vaccination status were the main independent variables associated with non-COVID-19 mortality. The odds ratio for in-hospital deaths of non-vaccinated patients was 2.01 (1.65-2.44) (unadjusted) and 1.61 (1.29-2.03) after adjustment for the independent variables. This "healthy adherer effect" may confound observational assessments of the clinical efficacy of COVID-19 vaccines.
我们检索了以色列一家地区医院的一组医疗患者的数据。因变量是非 COVID-19 医院死亡率；自变量是疫苗接种状态、年龄和实验室数据。血清钠、年龄、血清肌酐和 COVID-19 疫苗接种状态是与非 COVID-19 死亡率相关的主要独立变量。未接种疫苗患者住院死亡的优势比为 2.01（1.65-2.44）（未调整），调整独立变量后为 1.61（1.29-2.03）。这种“健康遵医效应”可能会混淆对 COVID-19 疫苗临床疗效的观察性评估。
