Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong 518055, China.
Department of Mechanical Engineering, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region.
Biomater Adv. 2022 Dec;143:213160. doi: 10.1016/j.bioadv.2022.213160. Epub 2022 Oct 18.
Polyetheretherketone (PEEK) is a potential bone repair material because of its stable chemical and good mechanical properties. However, the biological inertness of PEEK limits its clinical application. Sr has multi biological functions, including promoting bone formation and blood vessel regeneration and inhibiting inflammation. In this paper, PEEK was modified with Sr with the purpose to construct PEEK bone graft material with triple functions of osteogenesis, angiogenesis, and anti-inflammatory. The results showed that Sr-modified PEEK could stably release Sr for a long time in the PBS solution, and indeed could promote the proliferation and differentiation of osteoblasts, promote angiogenesis, and inhibit inflammation. Therefore, it is believed that this multifunctional PEEK with Sr should show great promise for clinical applications in bone repair.
聚醚醚酮（PEEK）是一种有潜力的骨修复材料，因为它具有稳定的化学性质和良好的机械性能。然而，PEEK 的生物惰性限制了其临床应用。锶具有多种生物学功能，包括促进骨形成和血管再生以及抑制炎症。在本文中，通过 Sr 对 PEEK 进行改性，目的是构建具有成骨、血管生成和抗炎三重功能的 PEEK 骨移植物材料。结果表明，Sr 改性 PEEK 可以在 PBS 溶液中稳定地长时间释放 Sr，并且确实可以促进成骨细胞的增殖和分化，促进血管生成，并抑制炎症。因此，人们相信这种具有 Sr 的多功能 PEEK 在骨修复的临床应用中应该具有很大的前景。
