Simorgh Sara, Alasvand Neda, Khodadadi Mahboobe, Ghobadi Faezeh, Malekzadeh Kebria Maziar, Brouki Milan Peiman, Kargozar Saeid, Baino Francesco, Mobasheri Ali, Mozafari Masoud
Cellular and Molecular Research Centre, Iran University of Medical Sciences, Tehran, Iran; Department of Tissue Engineering and Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran.
Department of Tissue Engineering and Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran; Department of Nanotechnology and Advanced Materials, Materials and Energy Research Center (MERC), Tehran, Iran.
Methods. 2022 Dec;208:75-91. doi: 10.1016/j.ymeth.2022.10.010. Epub 2022 Nov 2.
Tissue engineering (TE) and regenerative medicine have held great promises for the repair and regeneration of damaged tissues and organs. Additive manufacturing has recently appeared as a versatile technology in TE strategies that enables the production of objects through layered printing. By applying 3D printing and bioprinting, it is now possible to make tissue-engineered constructs according to desired thickness, shape, and size that resemble the native structure of lost tissues. Up to now, several organic and inorganic materials were used as raw materials for 3D printing; bioactive glasses (BGs) are among the most hopeful substances regarding their excellent properties (e.g., bioactivity and biocompatibility). In addition, the reported studies have confirmed that BG-reinforced constructs can improve osteogenic, angiogenic, and antibacterial activities. This review aims to provide an up-to-date report on the development of BG-containing raw biomaterials that are currently being employed for the fabrication of 3D printed scaffolds used in tissue regeneration applications with a focus on their advantages and remaining challenges.
组织工程（TE）和再生医学在受损组织和器官的修复与再生方面有着巨大的前景。增材制造最近作为一种通用技术出现在组织工程策略中，它能够通过分层打印来制造物体。通过应用3D打印和生物打印，现在可以根据所需的厚度、形状和尺寸制造出类似于受损组织天然结构的组织工程构建体。到目前为止，几种有机和无机材料被用作3D打印的原材料；生物活性玻璃（BGs）因其优异的性能（如生物活性和生物相容性）而成为最有希望的物质之一。此外，已报道的研究证实，BG增强的构建体可以提高成骨、血管生成和抗菌活性。本综述旨在提供一份关于含BG的原始生物材料发展的最新报告，这些材料目前正用于制造组织再生应用中使用的3D打印支架，重点关注它们的优势和仍然存在的挑战。
