Department of General Surgery, Third People's Hospital of Dalian, Dalian Medical University, 116033, Dalian, Liaoning, China.
Department of Central Laboratory, Third People's Hospital of Dalian, Dalian Medical University, 116033, Dalian, Liaoning, China.
Front Biosci (Landmark Ed). 2022 Oct 31;27(10):297. doi: 10.31083/j.fbl2710297.
Hashimoto's thyroiditis (HT) is the most common autoimmune disease involving the thyroid gland. HT often clinically manifest as hypothyroidism due to the destruction of thyroid cells mediated by humoral and cellular immunity. The pathogenesis of HT is a complex process in which environmental factors, hereditary inclination, trace elements immune factors, cytokines, and DNA and miRNA all play an important role. Herein, we summarize the precision factors involved in the pathogenesis of HT and offer an update over the past 5 years to provide a theoretical basis for further investigation of the relevant targets for HT treatment.
桥本甲状腺炎（HT）是最常见的甲状腺自身免疫性疾病。由于体液和细胞免疫介导的甲状腺细胞破坏，HT 常表现为临床甲状腺功能减退症。HT 的发病机制是一个复杂的过程，环境因素、遗传倾向、微量元素、免疫因素、细胞因子、DNA 和 miRNA 都起着重要作用。本文总结了 HT 发病机制中的精准因素，并对过去 5 年的研究进展进行了综述，为进一步研究 HT 的相关治疗靶点提供理论依据。
