McGee Daragh, Hanley Cathal, Reynolds Audrey, Smyth Shane
Catherine McCauley Centre for Education, University College Dublin, Dublin, Republic of Ireland.
Department of Neurology, Mater Misericordiae University Hospital, Dublin, Republic of Ireland.
Neuroophthalmology. 2022 Mar 2;46(5):319-321. doi: 10.1080/01658107.2022.2041046. eCollection 2022.
An independent 90-year-old woman presented to hospital with vivid and dynamic visual hallucinations following initiation of clarithromycin therapy. She had a background of previous cataract removal with good visual resolution and no significant deficits in visual acuity. Notably, she had been taking sertraline and quinine concurrently. Her symptoms fully resolved 72 hours following cessation of clarithromycin therapy. Visual hallucinations associated with clarithromycin could be explained by recent research demonstrating clarithromycin increases neuronal excitability by inhibiting gamma-aminobutyric acid-ergic signalling. Case reports of similar nature are rare, and we believe this report adds to a currently growing body of literature of visual hallucinations as a side effect of clarithromycin.
一名90岁的独立生活女性在开始使用克拉霉素治疗后出现生动且动态的视幻觉，随后入院。她既往有白内障摘除史，视力恢复良好，视力无明显缺陷。值得注意的是，她同时服用舍曲林和奎宁。在停止克拉霉素治疗72小时后，她的症状完全缓解。近期研究表明克拉霉素通过抑制γ-氨基丁酸能信号增加神经元兴奋性，这可以解释与克拉霉素相关的视幻觉。类似性质的病例报告很少见，我们认为本报告为目前不断增加的关于克拉霉素副作用导致视幻觉的文献增添了内容。
