Yan Xinlei, Sun Yufei, Yu Xiuli, Gao Jialu, Wang Hejing, Liang Ru, Han Wenying, Jin Xindong, Guo Wenhui, Liu Pufang, Chen Jia
College of Food Science and Engineering, Inner Mongolia Agricultural University, Hohhot, China.
College of Food Science and Engineering, Northwest Agriculture and Forestry University, Xianyang, Shaanxi, China.
Front Nutr. 2022 Oct 20;9:1032271. doi: 10.3389/fnut.2022.1032271. eCollection 2022.
is an obligate intracellular parasite that infects nucleated cells of all warm-blooded animals, and most patients have latent infections. The latent infection will be reactivated in the immunocompromised or immunocompromised individuals, which will lead to severe toxoplasmosis. At present, less research has been focused on the reactivation of infection. Koumiss is a kind of fermented milk made from fresh mare's milk through natural fermentation that can be applied to clinical and rehabilitation medicine to mitigate the development of various diseases due to its unique functional characteristics. In this study, we explored the antagonistic effect of koumiss on reactivation of infection. Mice were treated with dexamethasone to establish a reactivation model after infection with and then treated with koumiss. The survival rate, SHIRPA test, serum cytokine levels, organ parasite burden and intestinal microbiota were measured, respectively. Our results showed that koumiss treatment improved the clinical symptoms of mice, significantly reduced the organ parasite burden of mice, and improved the composition and structure of intestinal flora. This study provides new evidence for the alleviation and treatment of toxoplasmosis and provides a novel idea for the development and utilization of koumiss.
是一种专性细胞内寄生虫，可感染所有温血动物的有核细胞，大多数患者存在潜伏感染。潜伏感染会在免疫受损或免疫功能低下的个体中重新激活，从而导致严重的弓形虫病。目前，针对感染重新激活的研究较少。马奶酒是一种通过自然发酵由新鲜马奶制成的发酵乳，因其独特的功能特性可应用于临床和康复医学，以减轻各种疾病的发展。在本研究中，我们探讨了马奶酒对弓形虫感染重新激活的拮抗作用。小鼠在感染弓形虫后用 dexamethasone 处理以建立重新激活模型，然后用马奶酒处理。分别测量存活率、SHIRPA 试验、血清细胞因子水平、器官寄生虫负荷和肠道微生物群。我们的结果表明，马奶酒处理改善了小鼠的临床症状，显著降低了小鼠的器官寄生虫负荷，并改善了肠道菌群的组成和结构。本研究为弓形虫病的缓解和治疗提供了新证据，并为马奶酒的开发利用提供了新思路。
