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一名血清学阳性且有早产阵痛的孕妇发生脓毒症:一例险些发生严重后果的病例研究

Sepsis in a Seropositive Pregnant Woman With Early Preterm Labor Pains: A Case Study of a Near Miss.

作者信息

Singh Aarshika, Raka Mayur S, Rukhiyana Ronak H, Thadiboina Ooha

机构信息

Obstetrics and Gynaecology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Wardha, IND.

出版信息

Cureus. 2022 Oct 1;14(10):e29815. doi: 10.7759/cureus.29815. eCollection 2022 Oct.

Abstract

HIV is linked to a higher risk of preterm delivery in pregnant women. A systemic response to HIV virus can lead to foetus death along with patient death. Mortality is reduced in pregnant females and neonates by some interventions done carefully like antiretroviral therapy and prophylaxis, careful delivery methods, and monitoring of safe breastfeeding. Precautions are also used to decrease the mother-to-child transmission of HIV. An HIV-positive pregnant woman with sepsis is presented here to highlight the management of sepsis and labour. An HIV-positive primigravida on regular tenofovir, lamivudine, and efavirenz (TLE) regimen presented at 29 weeks and five days of her pregnancy to our outpatient department (OPD) with complaints of thick pus-like discharge and fever from seven to eight days. To manage it, labour was augmented by oxytocin in drip. Under all aseptic precautions, a breech 1.1kg male baby was delivered three hours later. Post-delivery status of the patient was uneventful except for two episodes of fever for two days serially on day five and day six. Both mother and the baby were discharged after 43 days of in-ward stay, both symptomatically alright. The mother was advised to continue antiretroviral therapy and get six monthly CD-4 (cluster of differentiation 4) counts for review and the baby was to be kept on top feeds till six months of age at the request of the patient. Keeping the following guidelines in mind, a multidisciplinary approach works best for such cases of HIV-infected mothers. However, it is necessary to individualise each patient.

摘要

人类免疫缺陷病毒(HIV)与孕妇早产风险较高有关。对HIV病毒的全身性反应可导致胎儿死亡以及患者死亡。通过精心实施一些干预措施,如抗逆转录病毒疗法和预防措施、谨慎的分娩方式以及安全母乳喂养监测,可降低孕妇和新生儿的死亡率。还采取了预防措施以减少HIV的母婴传播。本文介绍了一名患有败血症的HIV阳性孕妇,以突出败血症和分娩的管理。一名HIV阳性初产妇,正在接受替诺福韦、拉米夫定和依非韦伦(TLE)常规治疗方案,在怀孕29周零5天时因出现浓稠脓性分泌物和发热7至8天前来我院门诊就诊。为进行处理,通过静脉滴注催产素加强宫缩。在所有无菌预防措施下,3小时后分娩出一名体重1.1千克的臀位男婴。产后患者情况平稳,只是在第5天和第6天连续两天出现两次发热。住院43天后,母婴均出院,症状均已好转。建议母亲继续接受抗逆转录病毒治疗,并每6个月复查一次CD4(分化簇4)计数,应患者要求,婴儿应持续进行人工喂养至6个月大。牢记以下指南,多学科方法最适合此类HIV感染母亲的病例。然而,对每个患者进行个体化治疗很有必要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d291/9622034/0045d566348e/cureus-0014-00000029815-i01.jpg

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