Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Special Office for Prevention, Protection and High Vigilance, Sapienza University of Rome, Rome, Italy.
Front Public Health. 2022 Oct 19;10:1010130. doi: 10.3389/fpubh.2022.1010130. eCollection 2022.
To safely resume in-person activities during the COVID-19 pandemic, Sapienza University of Rome implemented rigorous infection prevention and control measures, a successful communication campaign and a free SARS-CoV-2 testing program. In this study, we describe the University's experience in carrying out such a program in the context of the COVID-19 response and identify risk factors for infection.
Having identified resources, space, supplies and staff, from March to June 2021 Sapienza offered to all its enrollees a molecular test service (8.30 AM to 4 PM, Monday to Thursday). A test-negative case-control study was conducted within the program. Participants underwent structured interviews that investigated activity-related exposures in the 2 weeks before testing. Multivariable conditional logistic regression analyses were performed. Adjusted odds ratios (aORs) and 95% confidence intervals (95% CIs) were calculated.
A total of 8,959 tests were administered, of which 56 were positive. The detection trend followed regional tendencies. Among 40 cases and 80 controls, multivariable analysis showed that a known exposure to a COVID-19 case increased the likelihood of infection (aOR: 8.39, 95% CI: 2.38-29.54), while having a job decreased it (aOR: 0.23, 95% CI: 0.06-0.88). Of factors that almost reached statistical significance, participation in activities in the university tended to reduce the risk (aOR: 0.32, 95% CI: 0.09-1.06), while attendance at private gatherings showed an increasing risk trend (aOR: 3.48, 95% CI: 0.95-12.79). Age, gender, activities in the community, visiting bars or restaurants, and use of public transportation were not relevant risk factors. When those students regularly attending the university campus were excluded from the analysis, the results were comparable, except that attending activities in the community came close to having a statistically significant effect (aOR: 8.13, 95% CI: 0.91-72.84).
The testing program helped create a safe university environment. Furthermore, promoting preventive behavior and implementing rigorous measures in public places, as was the case in the university setting, contributed to limit the virus transmission.
为了在 COVID-19 大流行期间安全地恢复面对面活动，罗马萨皮恩扎大学实施了严格的感染预防和控制措施、成功的沟通运动以及免费的 SARS-CoV-2 检测计划。在这项研究中，我们描述了大学在 COVID-19 应对背景下实施此类计划的经验，并确定了感染的危险因素。
从 2021 年 3 月到 6 月，在确定了资源、空间、供应品和人员之后，萨皮恩扎大学向其所有注册学生提供分子检测服务（周一至周四上午 8:30 至下午 4:00）。在该计划内开展了一项检测阴性病例对照研究。参与者接受了结构化访谈，调查了检测前两周与活动相关的暴露情况。进行了多变量条件逻辑回归分析。计算了调整后的优势比（aOR）和 95%置信区间（95%CI）。
共进行了 8959 次检测，其中 56 次呈阳性。检测趋势符合地区趋势。在 40 例病例和 80 例对照中，多变量分析表明，已知与 COVID-19 病例接触会增加感染的可能性（aOR：8.39，95%CI：2.38-29.54），而有工作则会降低感染的可能性（aOR：0.23，95%CI：0.06-0.88）。在几乎具有统计学意义的因素中，参加大学活动的风险降低（aOR：0.32，95%CI：0.09-1.06），而参加私人聚会的风险呈上升趋势（aOR：3.48，95%CI：0.95-12.79）。年龄、性别、社区活动、去酒吧或餐馆以及使用公共交通工具不是相关的危险因素。当从分析中排除那些经常在大学校园上课的学生时，结果是可比的，只是参加社区活动接近具有统计学意义的效果（aOR：8.13，95%CI：0.91-72.84）。
检测计划有助于营造安全的大学校园环境。此外，在公共场所促进预防行为和实施严格措施，如在大学环境中那样，有助于限制病毒传播。
