Zhang Shuxian, Zhang Hui, Li Lihua, Yang Xiaoyan, Li Shumao, Li Xuan
Clinical College of Ophthalmology, Tianjin Medical University, Tianjin, China.
Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Hospital, Tianjin, China.
Front Neurosci. 2022 Oct 20;16:986364. doi: 10.3389/fnins.2022.986364. eCollection 2022.
To study the effect of treatment zone (TZ) decentration on axial length growth (ALG) in adolescents after wearing the orthokeratology lenses (OK lenses).
This retrospective clinical study selected 251 adolescents who were fitted OK lenses at the Clinical College of Ophthalmology, Tianjin Medical University (Tianjin, China) from January 2018-December 2018 and wore them continuously for >12 months. The age of the subjects was 8-15 years, spherical equivalent (SE): -1.00 to -5.00 diopter (D), and astigmatism ≤ 1.50 D. The corneal topography were recorded at baseline and 1-, 6-, and 12-month visits, and the axial length (AL) were recorded at baseline and 6-, 12-month visits. The data of the right eye were collected for statistical analysis.
The subjects were divided into three groups according to the decentration distance of the TZ after wearing lenses for 1 month: 56 cases in the mild (<0.5 mm), 110 in the moderate (0.5-1.0 mm), and 85 in the severe decentration group (>1.0 mm). A significant difference was detected in the ALG between the three groups after wearing lenses for 6 and 12 months ( = 10.223, < 0.001; = 13.380, < 0.001, respectively). Among these, the 6- and 12-month ALG of the mild decentration group was significantly higher than that of the other two groups. Multivariable linear regression analysis showed that age, baseline SE, and 1-month decentration distance associated with the 12-month ALG ( < 0.001, < 0.001, and = 0.001, respectively).
The decentration of the TZ of the OK lens affected the growth of the AL in adolescents, i.e., the greater the decentration, the slower the ALG.
研究青少年佩戴角膜塑形镜（OK镜）后治疗区（TZ）偏心对眼轴长度增长（ALG）的影响。
这项回顾性临床研究选取了2018年1月至2018年12月在天津医科大学眼科临床学院（中国天津）验配OK镜并连续佩戴超过12个月的251名青少年。受试者年龄为8至15岁，等效球镜度（SE）：-1.00至-5.00屈光度（D），散光≤1.50 D。在基线以及1个月、6个月和12个月复诊时记录角膜地形图，在基线以及6个月、12个月复诊时记录眼轴长度（AL）。收集右眼数据进行统计分析。
根据佩戴镜片1个月后TZ的偏心距离将受试者分为三组：轻度偏心组（<0.5 mm）56例，中度偏心组（0.5 - 1.0 mm）110例，重度偏心组（>1.0 mm）85例。佩戴镜片6个月和12个月后，三组之间的ALG存在显著差异（分别为=10.223，<0.001；=13.380，<0.001）。其中，轻度偏心组6个月和12个月的ALG显著高于其他两组。多变量线性回归分析显示，年龄、基线SE和1个月偏心距离与12个月的ALG相关（分别为<0.001，<0.001，=0.001）。
OK镜TZ的偏心影响青少年眼轴的生长，即偏心越大，ALG越慢。
