Wang Wei, Gao Runshi, Ren Zhiwei, Yang Dongju, Sun Ke, Li Xiaoling, Yan Suying
Department of Pharmacy, Xuanwu Hospital, Capital Medical University, Beijing, China.
Department of Functional Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Front Neurosci. 2022 Oct 20;16:1042642. doi: 10.3389/fnins.2022.1042642. eCollection 2022.
Epilepsy affects more than 70 million people in the world. It is characterized by recurrent spontaneous seizures, and it is related to many neurological, cognitive, and psychosocial consequences. Glutamate neurotransmitter dysfunction has essential functions in the pathophysiology of epilepsy. In this work, bibliometric analysis was conducted to explore the trends, frontiers, and hotspots of the global scientific output of glutamate in epilepsy research in the past 20 years. The Science Citation Index Expanded of the Web of Science Core Collection (WoSCC) was searched to obtain information on publications and records published between 2002 and 2021. VOSviewer and CiteSpace were used to conduct bibliometric and visual analyses on the overall distribution of annual output, major countries, active institutions, journals, authors, commonly cited literature, and keywords. The impact and quality of the papers were assessed using the global citation score (GCS). Four thousand eight hundred ninety-one publications were retrieved in total. During the past two decades, the number of publications (Np) associated with glutamate in epilepsy has risen yearly. The United States has published the most papers; its H-index and number of citations are also the highest. The League of European Research Universities (LERU) was the most productive institution. In 2016, the total score of the paper written by Zhang Y was 854, ranking first. The keywords that appear most frequently are "epilepsy," "glutamate," "temporal lobe epilepsy (TLE)," "hippocampus," and "seizures." This study showed that although the publications related to epileptic glutamate fluctuated slightly, the Np increased overall. The United States is a great creator and influential country in this field. The first three authors are Eid, T., Aronica, E., and Smolders, I. "spectrum," "animal model," "inflammation," "mutation," "dysfunction," and "prefrontal cortex" are increasing research hotspots. By recognizing the most critical indicators (researchers, countries, research institutes, and journals of glutamate release in epilepsy research), the research hotspot of glutamate in epilepsy could help countries, scholars, and policymakers in this field enhance their understanding of the role of glutamate in epilepsy and make decisions.
癫痫影响着全球超过7000万人。其特征为反复出现的自发性癫痫发作，且与许多神经、认知和社会心理后果相关。谷氨酸神经递质功能障碍在癫痫的病理生理学中具有重要作用。在这项工作中，进行了文献计量分析，以探究过去20年中全球癫痫研究领域谷氨酸科学产出的趋势、前沿和热点。检索了科学网核心合集（WoSCC）的科学引文索引扩展版，以获取2002年至2021年间发表的出版物和记录信息。使用VOSviewer和CiteSpace对年产量的总体分布、主要国家、活跃机构、期刊、作者、被频繁引用的文献以及关键词进行文献计量和可视化分析。使用全球被引分数（GCS）评估论文的影响力和质量。总共检索到4891篇出版物。在过去二十年中，与癫痫中谷氨酸相关的出版物数量（Np）逐年上升。美国发表的论文最多；其H指数和被引次数也最高。欧洲研究型大学联盟（LERU）是产出最多的机构。2016年，张Y所写论文的总分是854分，排名第一。出现频率最高的关键词是“癫痫”“谷氨酸”“颞叶癫痫（TLE）”“海马体”和“癫痫发作”。这项研究表明，尽管与癫痫谷氨酸相关的出版物略有波动，但Np总体呈上升趋势。美国是该领域的重要创造者和有影响力的国家。前三作者是Eid, T.、Aronica, E.和Smolders, I. “光谱”“动物模型”“炎症”“突变”“功能障碍”和“前额叶皮层”是日益增加的研究热点。通过识别癫痫研究中谷氨酸释放的最关键指标（研究人员、国家、研究机构和期刊），癫痫中谷氨酸的研究热点可以帮助该领域的国家、学者和政策制定者增强对谷氨酸在癫痫中作用的理解并做出决策。
