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操作性条件作用如何对行为毒理学产生影响。

How operant conditioning can contribute to behavioral toxicology.

作者信息

Laties V G

出版信息

Environ Health Perspect. 1978 Oct;26:29-35. doi: 10.1289/ehp.782629.

Abstract

Operant conditioning can contribute to the development of behavioral toxicology in many ways. Its techniques are useful in training animals in the various behaviors the toxicologist may wish to study. They make possible the sophisticated assessment of sensory functioning. Operant conditioners excel at using schedules of intermittent reinforcement to create the type of stable animal performance needed in studying substances that produce effects only after prolonged exposure. Schedule-controlled behavior also helps elucidate the precise behavioral mechanisms involved in toxicity. In the early assessment of toxic substances a judiciously chosen sample of schelule-controlled performances may provide the best estimate whether the integrity of complex operant behavior remains unchanged. The development of improved behavioral techniques and computer technology promises to bring down the cost of such assessment.

摘要

操作性条件反射可以在许多方面促进行为毒理学的发展。其技术有助于训练动物做出毒理学家可能希望研究的各种行为。它们使对感觉功能进行精细评估成为可能。操作性条件反射擅长利用间歇性强化程序来建立研究仅在长期接触后才产生效应的物质所需的稳定动物行为模式。程序控制的行为也有助于阐明毒性所涉及的确切行为机制。在对有毒物质的早期评估中,精心挑选的程序控制行为样本可能会提供关于复杂操作性行为的完整性是否保持不变的最佳估计。改进的行为技术和计算机技术的发展有望降低此类评估的成本。

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本文引用的文献

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J Exp Anal Behav. 1968 Nov;11(6):651-60. doi: 10.1901/jeab.1968.11-651.
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