Li Lan, Feng Donglai, Zeng Jing, Ye Peng, Chen Yao, Wei Dong
Medical Examination Center, The Second People's Hospital of Chengdu, Chengdu, 610017, China.
Department of Endocrinology and Metabolism, Obesity and Metabolic Diseases Care Center, The Second People's Hospital of Chengdu, Chengdu, 610017, China.
Diabetol Metab Syndr. 2022 Nov 8;14(1):165. doi: 10.1186/s13098-022-00914-w.
Rheumatoid arthritis, metabolic syndrome (MS) and cardiovascular disease (CVD) are mutually connected. We aim to investigate the association between rheumatoid factor (RF) and MS in general population, explore the potential value of RF for assessment of metabolic status, and further provide a reference to the establishment of CVD primary prevention for this population.
We assessed the health check-up subjects, accordance with the inclusive criteria, from 1 January 2015 to 31 October 2021 in a large refereed general hospital, in this retrospective study. Subjects were categorized into four groups according to their levels of RF. Multivariate logistic regression models along with the Odds ratio (OR) and Confidence interval (CI) values were used to measure the association between RF and MS.
A total of 13,690 subjects were analyzed. Prevalence of MS increased with RF level (P for trend < 0.001). Logistic regression analysis showed that, after adjusting for multiple covariates, RF level was significantly associated with MS prevalence (highest RF quartile: OR, 1.420; 95% CI 1.275,1.581, according to the revised National Cholesterol Education Program Adult Treatment Panel III criteria; OR, 2.355; 95% CI 2.085,2.660, according to the International Diabetes Federation criteria) (both P for trends < 0.001). Among the MS components, there were evidence of increasing trends for overweight/obesity (highest RF quartile: OR, 3.165; 95% CI 2.827,3.543) and hypertension (highest RF quartile: OR, 1.722; 95% CI 1.549,1.914) (both P for trends < 0.001), but decreasing trend for low high-density lipoprotein-cholesterol (highest RF quartile: OR, 0.245; 95% CI 0.214,0.281) (P for trend < 0.001), with increasing RF quartiles.
RF level is associated with MS prevalence in general population. RF might be a valuable biomarker for assessment of metabolic status in this population. We should be aware of the cardiovascular risk for the higher-RF subjects.
类风湿关节炎、代谢综合征（MS）和心血管疾病（CVD）相互关联。我们旨在研究普通人群中类风湿因子（RF）与MS之间的关联，探索RF在评估代谢状态方面的潜在价值，并进一步为该人群心血管疾病一级预防的建立提供参考。
在这项回顾性研究中，我们评估了2015年1月1日至2021年10月31日期间在一家大型综合性三甲医院符合纳入标准的健康体检受试者。根据RF水平将受试者分为四组。使用多因素逻辑回归模型以及比值比（OR）和置信区间（CI）值来衡量RF与MS之间的关联。
共分析了13690名受试者。MS患病率随RF水平升高而增加（趋势P<0.001）。逻辑回归分析表明，在调整多个协变量后，RF水平与MS患病率显著相关（根据美国国家胆固醇教育计划成人治疗小组第三次修订标准，最高RF四分位数：OR，1.420；95%CI 1.275,1.581；根据国际糖尿病联盟标准，OR，2.355；95%CI 2.085,2.660）（趋势P均<0.001）。在MS的各组成部分中，超重/肥胖（最高RF四分位数：OR，3.165；95%CI 2.827,3.543）和高血压（最高RF四分位数：OR，1.722；95%CI 1.549,1.914）有增加趋势的证据（趋势P均<0.001），但随着RF四分位数增加，高密度脂蛋白胆固醇降低有下降趋势（最高RF四分位数：OR，0.245；95%CI 0.214,0.281）（趋势P<0.001）。
普通人群中RF水平与MS患病率相关。RF可能是评估该人群代谢状态的一个有价值的生物标志物。我们应该意识到高RF受试者的心血管风险。
