van Wietmarschen Herman, van Steenbergen Noortje, van der Werf Esther, Baars Erik
University of Applied Sciences Leiden, Anthroposophic Medicine, Leiden, the Netherlands.
Louis Bolk Institute, Department Nutrition & Health, Bunnik, the Netherlands.
Integr Med Res. 2022 Dec;11(4):100892. doi: 10.1016/j.imr.2022.100892. Epub 2022 Oct 9.
Antimicrobial resistance is a rapidly growing global issue affecting the effective treatment of infectious diseases. This provides a window of opportunity for the use and implementation of well researched effective complementary therapies such as herbal medicines. In this literature review, an overview is provided of the effectiveness of herbal medicine to control symptoms of urinary tract infections and reduce antibiotic use.
PubMed, CAM-Quest, CORE-Hom, ScienceDirect, CAMBase, Anthromedics.org and AnthroMedLibrary databases were searched for peer-reviewed meta-analyses, systematic reviews and randomized controlled trials from 2005 till 8 October 2020. Included were clinical studies on the use of herbal medicine for clinically diagnosed urinary tract infection with any control group except another herbal medicine. Study quality was assessed using the Joanna Briggs Institute critical appraisal tools.
Of the 408 citations identified, 23 met the inclusion criteria: 5 meta-analyses, 3 systematic reviews and 15 randomized controlled trials. Of these studies 13 involved the use of cranberry products, 4 studies concerned traditional Chinese herbal medicines, and 6 studies dealt with other herbal medicines.
The latest published meta-analysis including 28 trials reports a clear benefit of Cranberry products for the prevention of recurrent UTIs in women. Five TCM formulas were found to be equally or more effective than antibiotics in the treatment of UTIs. Furthermore, Rosa canina seems to have the potential to prevent UTI in women undergoing a caesarean section. 'Acidif Plus Tablets' as well as 'Canephron' seem to be promising candidates for treating women with uncomplicated recurrent UTI.
抗菌素耐药性是一个迅速发展的全球性问题，影响着传染病的有效治疗。这为使用和实施经过充分研究的有效补充疗法（如草药）提供了一个机会窗口。在这篇文献综述中，概述了草药控制尿路感染症状和减少抗生素使用的有效性。
检索了PubMed、CAM-Quest、CORE-Hom、ScienceDirect、CAMBase、Anthromedics.org和AnthroMedLibrary数据库，以查找2005年至2020年10月8日期间经过同行评审的荟萃分析、系统评价和随机对照试验。纳入的是关于使用草药治疗临床诊断的尿路感染的临床研究，对照组为除另一种草药外的任何对照组。使用乔安娜·布里格斯研究所的批判性评价工具评估研究质量。
在确定的408篇文献中，23篇符合纳入标准：包括5篇荟萃分析、3篇系统评价和15篇随机对照试验。在这些研究中，13项涉及蔓越莓产品的使用，4项研究涉及传统中草药，6项研究涉及其他草药。
最新发表的包括28项试验的荟萃分析报告称，蔓越莓产品对预防女性复发性尿路感染有明显益处。发现5种中药配方在治疗尿路感染方面与抗生素同样有效或更有效。此外，犬蔷薇似乎有预防剖宫产女性发生尿路感染的潜力。“Acidif Plus片”以及“Canephron”似乎是治疗非复杂性复发性尿路感染女性的有前景的候选药物。
