利用细胞色素 P450 酶的过氧酶活性高效脱除木质素单芳环。
Efficient -demethylation of lignin monoaromatics using the peroxygenase activity of cytochrome P450 enzymes.
机构信息
Department of Molecular and Biomedical Science, University of Adelaide, Adelaide, SA 5005, Australia.
Department of Chemistry, University of Adelaide, Adelaide, SA 5005, Australia.
出版信息
Chem Commun (Camb). 2022 Dec 1;58(96):13321-13324. doi: 10.1039/d2cc04698a.
A crucial reaction in harnessing renewable carbon from lignin is -demethylation. We demonstrate the selective -demethylation of syringol and guaiacol using different cytochrome P450 enzymes. These can efficiently use hydrogen peroxide which, when compared to nicotinamide cofactor-dependent monooxygenases and synthetic methods, allows for cheap and clean -demethylation of lignin-derived aromatics.
从木质素中获取可再生碳的关键反应是脱甲基化。我们利用不同的细胞色素 P450 酶对丁香酚和愈创木酚进行了选择性脱甲基化。这些酶可以有效地利用过氧化氢，与依赖烟酰胺辅酶的单加氧酶和合成方法相比，过氧化氢可以实现廉价、清洁的木质素衍生芳烃的脱甲基化。
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