Hao Zhi-You, Wang Xiao-Lan, Yang Meng, Cao Bing, Zeng Meng-Nan, Zhou Shi-Qi, Li Meng, Cao Yan-Gang, Xie Shuang-Shuang, Zheng Xiao-Ke, Feng Wei-Sheng
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, People's Republic of China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, 450046, People's Republic of China.
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, People's Republic of China; Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, 450046, People's Republic of China.
Phytochemistry. 2023 Jan;205:113505. doi: 10.1016/j.phytochem.2022.113505. Epub 2022 Nov 5.
Fifteen previously undescribed minor iridoid glycosides, including four monomers and eleven dimers, were isolated from the fruits of Cornus officinalis Sieb. et Zucc. Their chemical structures were determined on the basis of spectroscopic data and chemical evidence. All of the isolated compounds were evaluated for their effects of the glucose consumption on the insulin resistant HepG2 cells, and four compounds, named cornuofficinalisides F, H, L, and O, increased the glucose consumption significantly at 10 μM, the EC values of them were determined to be 0.898, 1.625, 0.923, and 8.589 μM, respectively. Moreover, the four compounds could improve the ability of glucose uptake significantly in insulin resistant HepG2 cells.
从山茱萸（Cornus officinalis Sieb. et Zucc.）果实中分离出15种此前未被描述的环烯醚萜苷类化合物，包括4种单体和11种二聚体。根据光谱数据和化学证据确定了它们的化学结构。对所有分离出的化合物进行了评估，考察其对胰岛素抵抗的HepG2细胞葡萄糖消耗的影响，4种化合物，即山茱萸苷F、H、L和O，在10 μM时显著增加葡萄糖消耗，它们的半数有效浓度（EC）分别测定为0.898、1.625、0.923和8.589 μM。此外，这4种化合物可显著提高胰岛素抵抗的HepG2细胞摄取葡萄糖的能力。
