Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing, China.
Qinghai Provincial Key Laboratory of Phytochemistry for Tibetan Plateau, Qinghai University for Nationalities, Xining, China.
Nat Prod Res. 2022 May;36(9):2329-2335. doi: 10.1080/14786419.2020.1834547. Epub 2020 Oct 14.
Five new secoiridoid glycosides, cornusphenosides E-I (-), were isolated and characterized from an active fraction of ethanol extract of the fruits of . Their structures were determined by extensive spectroscopic data analysis, including 2 D NMR and HRESIMS experiments. In the preliminary assay, compound (when evaluated at 10 M) showed the neuroprotective effect against HO-induced SH-SY5Y cell damage.
从Cornus officinalis果实的乙醇提取物的活性部分分离并鉴定了五个新的环烯醚萜苷，即cornusphenosides E-I (-)。通过广泛的光谱数据分析，包括 2D NMR 和 HRESIMS 实验，确定了它们的结构。在初步测定中，化合物 （当评估为 10M 时）表现出对 HO 诱导的 SH-SY5Y 细胞损伤的神经保护作用。
