成年人皮肤红斑狼疮的流行病学研究：跨越四十年（1976-2018）——狼疮中西部网络（LUMEN）研究。
Epidemiology of Cutaneous Lupus Erythematosus Among Adults Over Four Decades (1976-2018): A Lupus Midwest Network (LUMEN) Study.
机构信息
Division of Rheumatology, Mayo Clinic, Rochester, MN; Department of Medicine, University of Maryland Medical Center, Midtown Campus, Baltimore.
Department of Dermatology, Mayo Clinic, Rochester, MN.
出版信息
Mayo Clin Proc. 2022 Dec;97(12):2282-2290. doi: 10.1016/j.mayocp.2022.06.022. Epub 2022 Nov 5.
OBJECTIVE
To characterize the epidemiological trends and mortality of cutaneous lupus erythematosus (CLE) between 1976 and 2018 in Olmsted County, Minnesota.
PATIENTS AND METHODS
In this retrospective population-based cohort study, all incident and prevalent CLE cases among adult residents in Olmsted County, Minnesota, between January 1, 1976, and December 31, 2018, were identified and categorized by subtype through medical record review using the resources of the Rochester Epidemiology Project.
RESULTS
The overall incidence rate of CLE between 1976 and 2018 was 3.9 (95% CI, 3.4 to 4.5) per 100,000. The incidence of CLE was relatively stable, with no major trend across sexes or age groups. The age- and sex-adjusted prevalence of CLE was 108.9 per 100,000 on January 1, 2015. Mortality in CLE patients was similar to that of the general population, with a standardized mortality ratio of 1.23 (95% CI, 0.88 to 1.66) with no observed trends in mortality over time.
CONCLUSION
In the past 4 decades, the incidence of CLE remained stable. Patients with CLE have mortality comparable to that of the general population.
目的
描述明尼苏达州奥姆斯特德县 1976 年至 2018 年间皮肤红斑狼疮（CLE）的流行病学趋势和死亡率。
患者和方法
在这项回顾性基于人群的队列研究中，通过使用罗切斯特流行病学项目的资源对明尼苏达州奥姆斯特德县成年居民的所有新发病例和现患 CLE 病例进行了病历回顾，并根据亚型进行了分类。
结果
1976 年至 2018 年间，CLE 的总发病率为 3.9（95%CI，3.4 至 4.5）/100,000。CLE 的发病率相对稳定，性别或年龄组之间没有明显趋势。2015 年 1 月 1 日，经年龄和性别调整的 CLE 患病率为 108.9/100,000。CLE 患者的死亡率与普通人群相似，标准化死亡率比为 1.23（95%CI，0.88 至 1.66），死亡率随时间无明显趋势。
结论
在过去的 40 年中，CLE 的发病率保持稳定。CLE 患者的死亡率与普通人群相当。
Zotero 插件