Brissette J L, Cabacungan E A, Pieringer R A
J Biol Chem. 1986 May 15;261(14):6338-45.
Growth-inhibitory concentrations of racemic sn-1(3)-dodecylglycerol inhibit the incorporation of [14C] glycerol into lipids and lipoteichoic acid of Streptococcus mutans BHT and alter the per cent composition of the glycerolipids. Increases in phosphatidic acid and diphosphatidylglycerol (at the expense of phosphatidylglycerol) contribute the most to the change in lipid composition. No cellular lysis occurs under these conditions. Radioactive racemic sn-1(3)-dodecylglycerol is readily taken up by the cell and is metabolized primarily to lysophosphatidic acid and phosphatidic acid with smaller amounts converted to phosphatidylglycerol and diacylglycerol. The accumulation of phosphatidic acid and the loss of viability respond in parallel to different concentrations of dodecylglycerol. An increase in CTP is also observed which together with the increase in phosphatidic acid suggests a possible impairment in the synthesis of CDP-diacylglycerol.
外消旋sn-1(3)-十二烷基甘油的生长抑制浓度可抑制变形链球菌BHT将[14C]甘油掺入脂质和脂磷壁酸中，并改变甘油脂质的百分比组成。磷脂酸和二磷脂酰甘油的增加（以磷脂酰甘油为代价）对脂质组成的变化贡献最大。在这些条件下不会发生细胞裂解。放射性外消旋sn-1(3)-十二烷基甘油很容易被细胞摄取，主要代谢为溶血磷脂酸和磷脂酸，少量转化为磷脂酰甘油和二酰基甘油。磷脂酸的积累和活力丧失与不同浓度的十二烷基甘油呈平行反应。还观察到CTP增加，这与磷脂酸的增加一起表明CDP-二酰基甘油的合成可能受损。
