Chair of Exercise Physiology and Muscle Bioenergetics, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow, Poland.
PeerJ. 2022 Nov 3;10:e14228. doi: 10.7717/peerj.14228. eCollection 2022.
Angiogenesis is the physiological process of capillary growth. It is strictly regulated by the balanced activity of agents that promote the formation of capillaries (pro-angiogenic factors) on the one hand and inhibit their growth on the other hand (anti-angiogenic factors). Capillary rarefaction and insufficient angiogenesis are some of the main causes that limit blood flow during aging, whereas physical training is a potent non-pharmacological method to intensify capillary growth in the musculoskeletal system. The main purpose of this study is to present the current state of knowledge concerning the key signalling molecules implicated in the regulation of skeletal muscle and bone angiogenesis during aging and physical training.
血管生成是毛细血管生长的生理过程。它受到促进毛细血管形成的物质（促血管生成因子）和抑制其生长的物质（抗血管生成因子）的平衡活动的严格调节。毛细血管稀疏和血管生成不足是限制衰老过程中血液流动的主要原因之一，而体育锻炼是一种增强肌肉骨骼系统毛细血管生长的有效非药物方法。本研究的主要目的是介绍与衰老和体育锻炼过程中骨骼肌和骨骼血管生成调节相关的关键信号分子的最新知识。
