Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Proteomics. 2023 Jul;23(13-14):e2200208. doi: 10.1002/pmic.202200208. Epub 2022 Nov 17.
m6A is one of the most common, abundant, and conserved post-transcriptional modifications that regulate broad biological processes in the human body through m6A regulators. m6A regulators are figuratively classified according to their functions: writers, erasers, and readers, which can methylate RNAs, demethylate RNAs, and recognize RNA m6A sites, consequently affecting RNA fate. Tumors are an essential class of diseases that threaten human health, and as the study of m6A modification in tumors continues to advance, more and more relevant studies are emerging. In this review, we overview the recent studies of m6A in various types of tumors to demonstrate the role of m6A modification in providing a vision in diagnosing and treating tumors.
m6A 是最常见、最丰富和最保守的转录后修饰之一,通过 m6A 调节剂调节人体中的广泛生物学过程。m6A 调节剂根据其功能形象地分类:写入器、擦除器和读取器,它们可以使 RNA 甲基化、去甲基化和识别 RNA m6A 位点,从而影响 RNA 的命运。肿瘤是威胁人类健康的重要疾病类别,随着对肿瘤中 m6A 修饰的研究不断推进,越来越多的相关研究正在涌现。在这篇综述中,我们概述了 m6A 在各种类型肿瘤中的最新研究,以展示 m6A 修饰在提供肿瘤诊断和治疗的新视角中的作用。