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螺旋孔隙度对脑动脉瘤破裂风险降低的影响:计算研究。

Influence of the coiling porosity on the risk reduction of the cerebral aneurysm rupture: computational study.

机构信息

Mechanical Engineering Department, Politecnico di Milano, Milan, Italy.

Department of Mechanical Engineering, Babol Noshirvani University of Technology, Babol, Iran.

出版信息

Sci Rep. 2022 Nov 9;12(1):19082. doi: 10.1038/s41598-022-23745-1.

Abstract

The formation and progress of cerebral aneurysm is highly associated with hemodynamic factors and blood flow feature. In this study, comprehensive efforts are done to investigate the blood hemodynamic effects on the creation and growth of the Internal Carotid Artery. The computational fluid dynamic method is used for the visualization of the bloodstream inside the aneurysm. Transitional, non-Newtonian and incompressible conditions are considered for solving the Navier-Stokes equation to achieve the high-risk region on the aneurysm wall. OSI and WSS of the aneurysm wall are compared within different blood flow stages. The effects of blood viscosity and coiling treatment on these factors are presented in this work. Our study shows that in male patients (HCT = 0.45), changing the porosity of coiling from 0.89 with 0.79 would decreases maximum OSI up to 75% (in maximum acceleration). However, this effect is limited to about 45% for female patients (HCT = 0.35).

摘要

颅内动脉瘤的形成和发展与血流动力学因素和血流特征密切相关。在这项研究中,我们全面研究了血流动力学因素对内颈动脉的形成和生长的影响。我们使用计算流体动力学方法来可视化动脉瘤内的血流。考虑到过渡、非牛顿和不可压缩条件,来求解纳维-斯托克斯方程,以确定动脉瘤壁上的高风险区域。在不同的血流阶段,比较了动脉瘤壁上的 OSI 和 WSS。本工作还研究了血液粘度和线圈处理对这些因素的影响。我们的研究表明,在男性患者(HCT=0.45)中,将线圈的孔隙率从 0.89 变为 0.79,最大 OSI 最大加速度可降低 75%。然而,对于女性患者(HCT=0.35),这种影响的最大值限制在 45%左右。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7316/9646831/32be7fa4b9cc/41598_2022_23745_Fig1_HTML.jpg

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