Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, 250117, China.
Department of Medical Surgical Nursing, School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran.
Sci Rep. 2023 Nov 22;13(1):20461. doi: 10.1038/s41598-023-47867-2.
Diagnosis of aneurysm and possibility of aneurysm rupture are crucial for avoiding brain hemorrhage. In this work, blood stream inside internal carotid arteries (ICAs) are simulated in diverse working conditions to disclose the importance of hemodynamic factors on the rupture of aneurysm. The main attention of this study is to investigate the role of hemodynamic on the aneurysm rupture. Statistical and computational methods are applied to investigate coiling porosity and blood hematocrit in 9 specific real ICA geometries. Response surface model (RSM) develops 25 runs to investigate all features of selected geometrical parameters and treatment factors. Computational fluid dynamic is used for the simulation of the blood stream in the selected aneurysms. The effects of sac section area and mean radius of parent vessel on blood hemodynamics are fully investigated. Hemodynamic factors are examined and compared at the peak systolic time instant, including pressure distributions, and velocity. Achieved results indicate that the increasing sac section area (from 36.6 to 75.4 mm) results in 20% pressure reduction on the sac wall.
诊断动脉瘤和破裂的可能性对于避免脑出血至关重要。在这项工作中，模拟了各种工作条件下的颈内动脉（ICA）内部血流，以揭示血流动力学因素对动脉瘤破裂的重要性。本研究的主要关注点是研究血流动力学对动脉瘤破裂的作用。统计和计算方法用于研究 9 个特定真实 ICA 几何形状中的线圈孔隙率和血液血细胞比容。响应面模型（RSM）进行了 25 次运行，以研究所选几何参数和治疗因素的所有特征。计算流体动力学用于模拟所选动脉瘤中的血流。充分研究了囊段面积和母血管平均半径对血液动力学的影响。在收缩期峰值时间点检查和比较了血流动力学因素，包括压力分布和速度。结果表明，囊段面积的增加（从 36.6 增加到 75.4mm）会使囊壁上的压力降低 20%。
