Dept. of Neurosurgery, Shulan (Hangzhou) Hospital Affiliated to Zhejiang Shuren University Shulan International Medical College, Hangzhou, 310000, China.
Dept. of Hepatobiliary Surgery, Shulan (Hangzhou) Hospital Affiliated to Zhejiang Shuren University Shulan International Medical College, Hangzhou, 310000, China.
Sci Rep. 2024 Oct 4;14(1):23106. doi: 10.1038/s41598-024-73805-x.
This study investigates the influence of body physiology on the rupture risk of cerebral saccular aneurysms. Comprehensive hemodynamic analyses were conducted using computational fluid dynamics to assess the potential for aneurysm rupture under three physiological conditions: rest, normal activity, and exercise. Contours of wall shear stress, oscillatory shear index, and pressure were analyzed and compared to identify regions at high risk of rupture. Additionally, statistical analysis was performed to evaluate the rupture risk of aneurysms. Blood flow dynamics during the peak systolic phase were also examined under these conditions. Our findings indicate that the dome area, where blood pressure is highest and the incoming blood flow first contacts the aneurysm sac, is the critical region with a heightened risk of rupture.
本研究旨在探讨机体生理学对脑囊状动脉瘤破裂风险的影响。我们采用计算流体动力学对血流动力学进行了全面分析，以评估在三种生理条件下（休息、正常活动和运动）发生动脉瘤破裂的可能性。分析和比较了壁切应力、振荡剪切指数和压力的轮廓，以确定破裂风险较高的区域。此外，还进行了统计学分析以评估动脉瘤的破裂风险。在这些条件下，还检查了峰值收缩期的血流动力学。我们的研究结果表明，瘤顶区域（血压最高且初始血流与动脉瘤囊接触的区域）是破裂风险增加的关键区域。
