Department of Neurosurgery, The First Bethune Hospital of Jilin University, 130021, Changchun, Jilin, China.
Department of Pediatrics, The First Bethune Hospital of Jilin University, 130021, Changchun, Jilin, China.
Sci Rep. 2024 Sep 28;14(1):22500. doi: 10.1038/s41598-024-73231-z.
The present research extensively investigates the significance of the sac centerline length of the anterior cerebral artery (ACA) on aneurysm rupture risk. Hemodynamic factors influencing aneurysm rupture are assessed to identify critical regions prone to rupture. Wall shear stress is analyzed by modeling blood flow in three real saccular ACA cases with varying sac centerline lengths. A one-way fluid-solid interaction (FSI) model is employed to examine the interaction between blood flow and vessel deformation. The computational study reveals that wall shear stress on the ACA saccular aneurysm wall is significantly higher when the sac centerline length is shorter. Conversely, the mean oscillatory index changes with different sac centerline lengths, showing that an increase in sac centerline length leads to higher blood oscillation within the sac area in ACA cases.
本研究广泛探讨了大脑前动脉（ACA）囊中心长度对动脉瘤破裂风险的意义。评估影响动脉瘤破裂的血流动力学因素，以确定易破裂的关键区域。通过对三个具有不同囊中心长度的真实囊状 ACA 病例的血流进行建模，分析壁面剪切应力。采用单向流固相互作用（FSI）模型研究血流与血管变形之间的相互作用。计算研究表明，当囊中心长度较短时，ACA 囊状动脉瘤壁上的壁面剪切应力显著增加。相反，不同囊中心长度下的平均振荡指数发生变化，表明囊中心长度的增加会导致 ACA 病例中囊内区域的血液振荡增加。
