Sarrafzadegan Nizal, Mohammadifard Noushin, Javanmard Shaghayegh Haghjooy, Haghighatdoost Fahimeh, Nouri Fatemeh, Ahmadian Mahshid, Nasirian Maryam, Sayyah Maedeh, Najafian Jamshid, Shafiei Mohammadreza, Alikhasi Hassan, Javanbakht Sahel, Nilforoushzadeh Farzaneh, Bagheri Fahimeh, Shahidi Shahla, Rezaei Mostafa, Heidari Kamal, Keleidari Behrouz, Changiz Tahereh
Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
Faculty of Medicine, School of Population and Public Health, University of British Columbia, Vancouver, Canada.
J Res Med Sci. 2022 Aug 30;27:65. doi: 10.4103/jrms.jrms_552_21. eCollection 2022.
The Isfahan COVID Cohort (ICC) study was designed to investigate the short- and long-term consequences of patients with COVID-19 in Iran. This report presents the rationale, methodology, and initial results of ICC.
ICC is a 5-year multicentric prospective cohort study that is ongoing on two groups including 5000 patients hospitalized with moderate or severe and 800 nonhospitalized patients with mild or asymptomatic COVID-19 in Isfahan. The ICC endpoints are morbidity, mortality, incident cases, or worsening of underlying noncommunicable diseases (NCDs) and their risk factors. In the current analysis, we examined the persistent symptoms and incident NCDs or risk factors in 819 previously hospitalized patients who completed 1-year follow-up.
The two most common symptoms were joint pain/myalgia (19.7%) and dry cough/dyspnea (18.7%). Around 60% of patients had at least one symptom which was more common among women than men and in middle aged than younger or older patients. Female (odds ratio [OR] =1.88, 95% confidence interval [CI]: 1.39-2.55) and highly-educated patients (OR = 2.18, 95% CI: 1.56-3.04) had higher risk of having any symptom in 1-year follow-up. New cases of hypertension followed by diabetes then coronary heart disease (CHD) were the most common incident NCDs.
During 1-year follow-up after hospital discharge, about 60% of patients experienced persistent symptoms. Incident hypertension, diabetes, and CHD were the most common events seen. Close monitoring and extensive health services with integrative approaches are needed to improve the health status of these patients.
伊斯法罕新冠队列（ICC）研究旨在调查伊朗新冠肺炎患者的短期和长期后果。本报告介绍了ICC的基本原理、方法和初步结果。
ICC是一项为期5年的多中心前瞻性队列研究，目前正在进行，研究对象包括两组，一组是5000例因中度或重度新冠肺炎住院的患者，另一组是伊斯法罕800例轻度或无症状新冠肺炎非住院患者。ICC的终点指标是发病率、死亡率、发病病例，或潜在非传染性疾病（NCDs）及其危险因素的恶化情况。在当前分析中，我们检查了819例完成1年随访的既往住院患者的持续症状以及新发NCDs或危险因素。
两种最常见的症状是关节痛/肌痛（19.7%）和干咳/呼吸困难（18.7%）。约60%的患者至少有一种症状，女性比男性更常见，中年患者比年轻或老年患者更常见。女性（优势比[OR]=1.88，95%置信区间[CI]：1.39-2.55）和高学历患者（OR=2.18，95%CI：1.56-3.04）在1年随访中有任何症状的风险更高。高血压新发病例其次是糖尿病，然后是冠心病（CHD）是最常见的新发NCDs。
出院后1年随访期间，约60%的患者出现持续症状。新发高血压、糖尿病和冠心病是最常见的情况。需要密切监测并采用综合方法提供广泛的医疗服务，以改善这些患者的健康状况。
