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唇部多形性腺瘤:一例报告并文献复习

Pleomorphic adenoma of the lip: a case report and literature review.

作者信息

Ali Rawa M, Ali Rebaz M, Qaradakhy Aras J, Hiwa Dilan S, Abdullah Ari M, Omar Diyar A, Hassan Shko H, Qadir Abdullah A, Salih Abdulwahid M, Kakamad Fahmi H

机构信息

Scientific Affairs Department, Smart Health Tower, Madam Mitterrand Street, Sulaymaniyah 46001, Iraq.

Hospital for Treatment of Victims of Chemical Weapons, Mawlawy Street, Halabja 46018, Iraq.

出版信息

J Surg Case Rep. 2025 May 15;2025(5):rjaf311. doi: 10.1093/jscr/rjaf311. eCollection 2025 May.

DOI:10.1093/jscr/rjaf311
PMID:40376544
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12078932/
Abstract

Pleomorphic adenoma (PA) most commonly affects the major salivary glands but can also involve the minor salivary glands, particularly those of the hard and soft palate. However, the current study aims to present a case of upper lip PA. A 29-year-old male presented with a painless, firm, slow-growing swelling (1.5 × 1.5 cm) on the left upper lip. Ultrasonography showed a solid, hypoechoic nodule with irregular margins and mild peripheral vascularity. The encapsulated tumor was excised, and histopathology confirmed PA. At the 7-month follow-up, no evidence of recurrence was observed. Though typically seen in adults aged 40-70, PA can affect younger patients. Complete excision with clear margins is essential due to the risk of recurrence or malignant transformation. PA should be considered in the differential diagnosis of upper lip swellings.

摘要

多形性腺瘤(PA)最常累及大唾液腺,但也可累及小唾液腺,尤其是硬腭和软腭的小唾液腺。然而,本研究旨在报告一例上唇多形性腺瘤病例。一名29岁男性患者,左上唇出现一个无痛、质地硬、生长缓慢的肿块(1.5×1.5厘米)。超声检查显示为一个实性、低回声结节,边界不规则,周边血管轻度增多。完整切除该包膜肿瘤,组织病理学确诊为多形性腺瘤。在7个月的随访中,未观察到复发迹象。虽然多形性腺瘤通常见于40至70岁的成年人,但也可影响年轻患者。由于存在复发或恶变风险,完整切除且切缘清晰至关重要。在鉴别诊断上唇肿胀时应考虑多形性腺瘤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3de/12078932/71cc7ede0e2d/rjaf311f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3de/12078932/389ccc6c3402/rjaf311f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3de/12078932/71cc7ede0e2d/rjaf311f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3de/12078932/389ccc6c3402/rjaf311f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3de/12078932/71cc7ede0e2d/rjaf311f2.jpg

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本文引用的文献

1
Lip pleomorphic adenomas: case series and literature review.唇部多形性腺瘤:病例系列及文献综述。
Gland Surg. 2022 Oct;11(10):1730-1740. doi: 10.21037/gs-22-308.
2
Chromosome Translocations, Gene Fusions, and Their Molecular Consequences in Pleomorphic Salivary Gland Adenomas.多形性腺瘤中的染色体易位、基因融合及其分子后果
Biomedicines. 2022 Aug 14;10(8):1970. doi: 10.3390/biomedicines10081970.
3
Rare upper lip pleomorphic adenoma presents as cutaneous skin lesion: Case report.罕见的上唇多形性腺瘤表现为皮肤病变:病例报告。
Int J Surg Case Rep. 2021 Aug;85:106142. doi: 10.1016/j.ijscr.2021.106142. Epub 2021 Jun 29.
4
Pleomorphic adenoma of the upper lip.上唇多形性腺瘤
Natl J Maxillofac Surg. 2020 Jan-Jun;11(1):110-112. doi: 10.4103/njms.NJMS_55_17. Epub 2020 Jun 18.
5
Pleomorphic Adenoma of the Upper Lip: A Case Report.上唇多形性腺瘤:一例报告
Saudi J Med Med Sci. 2018 Jan-Apr;6(1):32-35. doi: 10.4103/sjmms.sjmms_109_16. Epub 2017 Dec 14.