Department of Oncology, The Second Xiangya Hospital, Central South University, Changsha, China.
Xiangya School of Medicine, Central South University, Changsha, China.
Front Immunol. 2022 Oct 24;13:996663. doi: 10.3389/fimmu.2022.996663. eCollection 2022.
Activation of the cGAS-STING pathway by cytoplasmic DNA induces the production of Type-1 interferons. Recent advances in research suggest that the cGAS-STING pathway is involved in different parts of the cancer-immunity cycle (CIC) to promote or suppress antitumor immune responses. Combination therapy of STING agonists has made certain progress in preclinical as well as clinical trials, but the selection of combination therapy regimens remains a challenge. In this review, we summarize the role of the cGAS-STING in all aspects of CIC, and focus on the combination immunotherapy strategies of STING agonists and current unsolved challenges.
cGAS-STING 通路被细胞质 DNA 激活后会诱导 I 型干扰素的产生。最近的研究进展表明，cGAS-STING 通路参与癌症免疫循环（CIC）的不同部分，以促进或抑制抗肿瘤免疫反应。STING 激动剂的联合治疗在临床前和临床试验中都取得了一定的进展，但联合治疗方案的选择仍然是一个挑战。在这篇综述中，我们总结了 cGAS-STING 在 CIC 各个方面的作用，并重点介绍了 STING 激动剂的联合免疫治疗策略以及当前尚未解决的挑战。
